ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2014
Can we improve the clinical risk score? The prognostic value of p53, Ki-67 and thymidylate synthase in patients undergoing radical resection of colorectal liver metastases.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Increased expression of Ki-67 is a poor prognostic marker for colorectal cancer patients: a meta analysis.BMC cancer · 2019Pooled it
- Influencing factors and predictive model of the early postoperative recurrence of colorectal cancer with obstruction.World journal of gastrointestinal surgery · 2025Article
- Indocyanine green-assisted liver resection for colorectal liver metastases and factors associated with resection margin: a single-center retrospective study.World journal of surgical oncology · 2025Article
- Ranking as a Procedure for Selecting a Replacement Variable in the Score Predicting the Survival of Patients Treated with Curative Intent for Colorectal Liver Metastases.Medicina (Kaunas, Lithuania) · 2023Article
- Review
- Green Synthesized Gold and Silver Nanoparticles Increased Oxidative Stress and Induced Cell Death in Colorectal Adenocarcinoma Cells.Nanomaterials (Basel, Switzerland) · 2023Article
- Ki67 testing in the clinical management of patients with non-metastatic colorectal cancer: Detecting the optimal cut-off value based on the Restricted Cubic Spline model.Oncology letters · 2022Article
- Stage IV colon cancer patients without DENND2D expression benefit more from neoadjuvant chemotherapy.Cell death & disease · 2022Article
- Biomarkers in colorectal liver metastases: Rising complexity and unknown clinical significance?Annals of gastroenterological surgery · 2021Review
- Efficacy and safety of short duration radiotherapy combined with chemotherapy for advanced rectal cancer.World journal of clinical cases · 2021Article
- Clinical Significance and Prognostic Value of the Maximum Standardized Uptake Value ofFrontiers in oncology · 2021Article
- Colorectal Liver Metastases: Does the Future of Precision Medicine Lie in Genetic Testing?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Review
- Simultaneous Pure Laparoscopic Resection of Primary Colorectal Cancer and Synchronous Liver Metastases: A Single Institution Experience with Propensity Score Matching Analysis.Radiology and oncology · 2018Article
- Immunohistochemical investigation of prognostic biomarkers in resected colorectal liver metastases: a systematic review and meta-analysis.Cancer cell international · 2018Review
- Molecular markers of prognosis and therapeutic targets in metastatic colorectal cancer.Surgical oncology · 2016Review
- Surgery for colorectal liver metastases: The evolution of determining prognosis.World journal of gastrointestinal oncology · 2013Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to assess whether biological markers can provide prognostic information additional to that supplied by the clinical risk score (CRS) in patients with colorectal liver metastases.
methodsA retrospective review of a prospectively maintained database was conducted. Patients selected for this study were treated between 1996 and 2011 with potentially curative liver surgery. Expressions of p53, Ki-67 and thymidylate synthase were assayed using immunohistochemical techniques on tissue microarrays.
resultsA total of 98 (24%) of 406 patients met the inclusion criteria. The median follow-up was 103 months. Analysis revealed a correlation between p53 protein overexpression and high CRS (P = 0.058). Following multivariate analysis, only high CRS remained as an independent negative prognostic predictor of survival (P = 0.018), as well as an indicator of early recurrence of disease (P = 0.010). Of the biological markers investigated, only Ki-67 overexpression was identified as a positive predictor of survival on multivariate analysis (P = 0.038).
conclusionsKi-67 overexpression was a positive predictor of survival. Only high CRS remained an independent negative prognostic predictor.
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