ArticleCritical care (London, England)2013
Citrulline: just a biomarker or a conditionally essential amino acid and a pharmaconutrient in critically ill patients?
Article in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Controlled Randomized Multi-centric Clinical Trial on the Effect of Citrulline on the Clinical and Biochemical Evolution of Patients With Sepsis.
Evaluation of the Effect of Nutritional Supplementation and Pulmonary Rehabilitation on the Clinical Status of Patients With Heart Failure and Chronic Obstructive Pulmonary Disease
Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Trial
- Granulocytic myeloid-derived suppressor cells inversely correlate with plasma arginine and overall survival in critically ill patients.Clinical and experimental immunology · 2015Trial
- Antidepressant Effects of L-Arginine and Its Role in Brain Energy MetabolismIranian biomedical journal · 2026Article
- Muscle protein catabolism and splanchnic arginine consumption drive arginine dysregulation duringAmerican journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Leigh Syndrome due toMolecular syndromology · 2024Article
- The Effect of L-Citrulline Supplementation on Outcomes of Critically Ill Patients under Mechanical Ventilation; a Double-Blind Randomized Controlled Trial.Archives of academic emergency medicine · 2023Article
- Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study.Frontiers in psychiatry · 2020Article
- Lack of relationship between fasting plasma citrulline and glucose absorption: do not underestimate the role of the failing kidney!Critical care (London, England) · 2019Article
- L-Arginine and L-Citrulline Supplementation Have Different Programming Effect on Regulatory T-Cells Function of Infantile Rats.Frontiers in immunology · 2018Article
- Plasma citrulline in the critically ill: intriguing biomarker, cautious interpretation.Critical care (London, England) · 2015Article
- Arginine and citrulline and the immune response in sepsis.Nutrients · 2015Review
- The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill.Critical care (London, England) · 2015Observational
- Emerging therapeutic targets of sepsis-associated acute kidney injury.Seminars in nephrology · 2015Review
- Novel metabolic roles of L-arginine in body energy metabolism and possible clinical applications.The journal of nutrition, health & aging · 2014Article
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low plasma citrulline levels have been associated with a reduction of functional gut mass in various clinical situations. In critically ill patients, citrulline variations are tricky to interpret because of sepsis, vascular abnormalities, and multiple organ failure. In the previous issue of Critical Care, Ware and colleagues made an important contribution by demonstrating that very low citrulline levels are associated with acute respiratory distress syndrome. This association may be due to a decrease in citrulline availability or citrulline overconsumption for nitric oxide synthesis but also may result from an arginine deficiency syndrome. In any case, the results of this study reinforce the rationale for a study of citrulline supplementation in critically ill patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.