ReviewBioMed research international2013
Restoring fertility in sterile childhood cancer survivors by autotransplanting spermatogonial stem cells: are we there yet?
Review in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Cryopreservation of Sperm: A Review.Cureus · 2022Review
- The Role of MicroRNA 143 and MicroRNA 206 in The Regulation of Apoptosis in Mouse Lukemia Cancer Cells and Spermatogonial Cells.Cell journal · 2021Article
- ITGA6+ Human Testicular Cell Populations Acquire a Mesenchymal Rather than Germ Cell Transcriptional Signature during Long-Term Culture.International journal of molecular sciences · 2020Article
- Separating mouse malignant cell line (EL4) from neonate spermatogonial stem cells utilizing microfluidic device in vitro.Stem cell research & therapy · 2020Article
- Article
- Identification of Premeiotic, Meiotic, and Postmeiotic Cells in Testicular Biopsies Without Sperm from Sertoli Cell-Only Syndrome Patients.International journal of molecular sciences · 2019Article
- Recent advances of in vitro culture systems for spermatogonial stem cells in mammals.Reproductive medicine and biology · 2018Review
- Long-term health in recipients of transplanted in vitro propagated spermatogonial stem cells.Human reproduction (Oxford, England) · 2018Article
- Process and Pitfalls of Sperm Cryopreservation.Journal of clinical medicine · 2017Review
- Listening through narratives: using a narrative approach when discussing fertility preservation options with young cancer patients.Current oncology (Toronto, Ont.) · 2017Article
- Article
- Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic diseases.Human reproduction update · 2016Review
- [Androprotect and prospects for fertility treatment].Der Urologe. Ausg. A · 2016Review
- Chemokine (C-X-C) Ligand 12 Facilitates Trafficking of Donor Spermatogonial Stem Cells.Stem cells international · 2016Article
- VSELs may obviate cryobanking of gonadal tissue in cancer patients for fertility preservation.Journal of ovarian research · 2015Article
- AZFc deletions do not affect the function of human spermatogonia in vitro.Molecular human reproduction · 2015Article
- Spermatogonial stem cells: Current biotechnological advances in reproduction and regenerative medicine.World journal of stem cells · 2015Article
- Making gametes from pluripotent stem cells--a promising role for very small embryonic-like stem cells.Reproductive biology and endocrinology : RB&E · 2014Article
- Fertility preservation in the male with cancer.Current urology reports · 2013Review
- Spermatogonial stem cells as a therapeutic alternative for fertility preservation of prepubertal boys.Einstein (Sao Paulo, Brazil)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current cancer treatment regimens do not only target tumor cells, but can also have devastating effects on the spermatogonial stem cell pool, resulting in a lack of functional gametes and hence sterility. In adult men, fertility can be preserved prior to cancer treatment by cryopreservation of ejaculated or surgically retrieved spermatozoa, but this is not an option for prepubertal boys since spermatogenesis does not commence until puberty. Cryopreservation of a testicular biopsy taken before initiation of cancer treatment, followed by in vitro propagation of spermatogonial stem cells and subsequent autotransplantation of these stem cells after cancer treatment, has been suggested as a way to preserve and restore fertility in childhood cancer survivors. This strategy, known as spermatogonial stem cell transplantation, has been successful in mice and other model systems, but has not yet been applied in humans. Although recent progress has brought clinical application of spermatogonial stem cell autotransplantation in closer range, there are still a number of important issues to address. In this paper, we describe the state of the art of spermatogonial stem cell transplantation and outline the hurdles that need to be overcome before clinical implementation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.