ArticleBioMed research international2013
Signal transducer and activator of transcription factor 6 signaling contributes to control host lung pathology but favors susceptibility against Toxocara canis infection.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- The potential relationship between Toxocara canis infection and epilepsy in a rat model.Parasitology research · 2025Article
- Efficacy of artemether against toxocariasis in mice: parasitological and immunopathological changes in brain, liver, and lung.Pathogens and global health · 2024Article
- Effects of metformin on parasitological, pathological changes in the brain and liver and immunological aspects during visceral toxocariasis in mice.Parasitology research · 2023Article
- Class switching is differentially regulated in RBC alloimmunization and vaccination.Transfusion · 2023Article
- Assessment of the efficacy of thymol againstJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Modulation of STAT-1, STAT-3, and STAT-6 activities in THP-1 derived macrophages infected with twoFrontiers in immunology · 2022Article
- Identification ofPathogens (Basel, Switzerland) · 2021Article
- Bone marrow mesenchymal stem cell co-adjuvant therapy with albendazole for managingVeterinary world · 2021Article
- A Dual Role for Macrophages in Modulating Lung Tissue Damage/Repair during L2Pathogens (Basel, Switzerland) · 2019Article
- Cytokine production and signalling in human THP-1 macrophages is dependent on Toxocara canis glycans.Parasitology research · 2019Article
- Role of Macrophages in the Repair Process during the Tissue Migrating and Resident Helminth Infections.BioMed research international · 2016Review
- Toxocara canis mucins among other excretory-secretory antigens induce in vitro secretion of cytokines by mouse splenocytes.Parasitology research · 2015Article
- Immunopathological changes in the brain of immunosuppressed mice experimentally infected with Toxocara canis.The Korean journal of parasitology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using STAT6(-/-) BALB/c mice, we have analyzed the role of STAT6-induced Th2 response in determining the outcome of experimental toxocariasis caused by embryonated eggs of the helminth parasite Toxocara canis. Following T. canis infection wild-type BALB/c mice developed a strong Th2-like response, produced high levels of IgG1, IgE, and IL-4, recruited alternatively activated macrophages, and displayed a moderate pathology in the lungs; however, they harbored heavy parasite loads in different tissues. In contrast, similarly infected STAT6(-/-) BALB/c mice mounted a weak Th2-like response, did not recruit alternatively activated macrophages, displayed a severe pathology in the lungs, but efficiently controlled T. canis infection. These findings demonstrate that Th2-like response induced via STAT6-mediated signaling pathway mediates susceptibility to larval stage of T. canis. Furthermore, they also indicate that unlike most gastrointestinal helminths, immunity against larvae of T. canis is not mediated by a Th2-dominant response.
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