ArticleBioMed research international2013
Hydrogen bond acceptors and additional cationic charges in methylene blue derivatives: photophysics and antimicrobial efficiency.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Safe-by-redesign guidance for toxic industrial chemicals using explainable artificial intelligence: Introducing the DETOX-QSAR model.Scientific reports · 2026Article
- A new model measuring bacterial phagocytosis and phagolysosomal oxidation in humans using the intradermal injection of methylene blue-labeled Escherichia coli.Journal of leukocyte biology · 2025Article
- Saliva-derived components can enhance the performance of toluidine blue in photodynamic therapy.Frontiers in pharmacology · 2025Article
- Concanavalin A Delivers a Photoactive Protein to the Bacterial Wall.International journal of molecular sciences · 2024Article
- Photodynamic Therapy, Probiotics, Acetic Acid, and Essential Oil in the Treatment of Chronic Wounds Infected withPharmaceutics · 2023Review
- Amphiphilic di-cationic methylene blue for improving antibacterial photodynamic efficiency through high accumulation and low aggregation on bacterial cell surfaces.RSC advances · 2022Article
- Towards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-Molecules (Basel, Switzerland) · 2022Article
- Structure, physicochemical properties, and adsorption performance of the ethyl cellulose/bentonite composite films.Cellulose (London, England) · 2022Article
- Clinical applications of antimicrobial photodynamic therapy in dentistry.Frontiers in microbiology · 2022Review
- Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy.Molecules (Basel, Switzerland) · 2020Review
- Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics.Nano-micro letters · 2020Review
- Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye-Labeled Cargo.Angewandte Chemie (International ed. in English) · 2020Article
- Photosensitizers in antibacterial photodynamic therapy: an overview.Laser therapy · 2018Review
- Photodynamic antimicrobial activity of new porphyrin derivatives against methicillin resistant Staphylococcus aureus.Journal of microbiology (Seoul, Korea) · 2018Article
- Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections.Journal of clinical and translational research · 2015Review
- The impact of absorbed photons on antimicrobial photodynamic efficacy.Frontiers in microbiology · 2015Article
- Antimicrobial photodynamic therapy for inactivation of biofilms formed by oral key pathogens.Frontiers in microbiology · 2014Review
- A comprehensive tutorial on in vitro characterization of new photosensitizers for photodynamic antitumor therapy and photodynamic inactivation of microorganisms.BioMed research international · 2013Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photodynamic inactivation of bacteria (PIB) by efficient singlet oxygen photosensitizers might be a beneficial alternative to antibiotics in the struggle against multiresistant bacteria. Phenothiazinium dyes belong to the most prominent classes of such sensitizers due to their intense absorption in the red-light region (λ(abs, max) ca. 600-680 nm, ε > 50,000 L mol(-1) cm(-1)), their low toxicity, and their attachment/penetration abilities. Except simple substituents like alkyl or hydroxyalkyl residues, nearly no modifications of the phenothiaziniums have been pursued at the auxochromic sites. By this, the properties of methylene blue derivatives and their fields of application are limited; it remains unclear if their potential antimicrobial efficacy may be enhanced, also to compete with porphyrins. We prepared a set of six mainly novel methylene blue derivatives with the ability of additional hydrogen bonding and/or additional cationic charges to study the substituents' effect on their activity/toxicity profiles and photophysical properties. Direct detection of singlet oxygen was performed at 1270 nm and the singlet oxygen quantum yields were determined. In suspensions with both, gram-positive and gram-negative bacteria, some derivatives were highly active upon illumination to inactivate S. aureus and E. coli up to 7 log10 steps (99.99999%) without inherent toxicities in the nonirradiated state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.