Evidence map›Paper›PMID 23509708›Full record

ArticleBioMed research international2013

Heparin and carboxymethylchitosan metal nanoparticles: an evaluation of their cytotoxicity.

Adriana Bava, Francesca Cappellini, Elisa Pedretti, Federica Rossi, Enrico Caruso, Elena Vismara, Maurizio Chiriva-Internati, Giovanni Bernardini, Rosalba Gornati

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Adriana BavaDipartimento di Biotecnologie e Scienze della Vita, Università dell'Insubria, 21100 Varese, Italy.
Francesca Cappellini
Elisa Pedretti
Federica Rossi
Enrico Caruso
Elena Vismara
Maurizio Chiriva-Internati
Giovanni Bernardini
Rosalba Gornati
University of Insubria · ITTexas Tech University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the search for noninvasive diagnostic techniques and new therapies, "nanosystems", which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also because they are considered capable to mask nanoparticle toxicity. In this work, we have compared the toxicity of nanoparticles coated with heparin and carboxymethylchitosan in the SKOV-3 cell line. Our results indicate that heparin and carboxymethylchitosan coatings do not guarantee the decrease of nanoparticle intrinsic toxicity which is often envisaged. Nonetheless, these coatings provide the opportunity for further functionalization with a variety of biomolecules for their use in theranostics.

Indexed as

Biocompatible MaterialsCell LineCell SurvivalChitosanDrug CarriersHeparinHumansIronMetal NanoparticlesMicroscopy, Electron, TransmissionSpectroscopy, Fourier Transform InfraredStatic ElectricityBiocompatible Materialscarboxymethyl-chitosanChitosanDrug CarriersHeparinIron

Identifiers

PMID23509708
PMCPMC3590581
OpenAlexW2084980693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.