ReviewBioMed research international2013
Immune responses associated with resistance to haemonchosis in sheep.
Review in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 108 citations in OpenAlex.
- Comparison of Th-2 Cytokines and Associated Gene Expression in Peripheral Blood of Resistant and Susceptible Garole Sheep Infected WithJournal of parasitology research · 2026Article
- Uncovering functional INDELs responsible for splice sites in sheep with different immune profiles naturally exposed to gastrointestinal nematode infection.Scientific reports · 2025Article
- Physical and Numerical Investigation of Hot Deformation Behavior in Medium-Mn Steel for Automotive Forgings.Materials (Basel, Switzerland) · 2025Article
- Classification of productive hair ewes using hematocrit as a marker of resistance to gastrointestinal nematodes.Open veterinary journal · 2025Article
- Inferring the energy cost of resistance to parasitic infection and its link to a trade-off.BMC ecology and evolution · 2025Article
- Tannin alleviated reproductive dysfunction in pregnant ewes infected withFrontiers in veterinary science · 2025Article
- Immune modulation of buffalo peripheral blood mononuclear cells by two asparaginyl endopeptidases from Fasciola gigantica.Parasites & vectors · 2024Article
- Classification Performance of Machine Learning Methods for Identifying Resistance, Resilience, and Susceptibility toAnimals : an open access journal from MDPI · 2023Article
- Identifying hepatic genes regulating the ovine response to gastrointestinal nematodes using RNA-Sequencing.Frontiers in genetics · 2023Article
- Prevalence and resistance to gastrointestinal parasites in goats: A review.Veterinary world · 2022Review
- An Artemisia cina n-hexane extract reduces the Haemonchus contortus and Teladorsagia circumcincta fecal egg count in naturally infected periparturient goats.Tropical animal health and production · 2022Article
- Physiological, Immunological and Genetic Factors in the Resistance and Susceptibility to Gastrointestinal Nematodes of Sheep in the Peripartum Period: A Review.Helminthologia · 2021Article
- Effect ofAnimals : an open access journal from MDPI · 2021Article
- Modulation of the Functions of Goat Peripheral Blood Mononuclear Cells byPathogens (Basel, Switzerland) · 2020Article
- Recombinant elongation factor 1 alpha of Haemonchus contortus affects the functions of goat PBMCs.Parasite immunology · 2020Article
- Resistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response.Scientific reports · 2019Article
- Signatures of selection for resistance to Haemonchus contortus in sheep and goats.BMC genomics · 2019Article
- HcTTR: a novel antagonist against goat interleukin 4 derived from the excretory and secretory products of Haemonchus contortus.Veterinary research · 2019Article
- Variation in phenotypic resistance to gastrointestinal nematodes in hair sheep in the humid tropics of Mexico.Parasitology research · 2019Article
- Transcriptome analysis unraveled potential mechanisms of resistance to Haemonchus contortus infection in Merino sheep populations bred for parasite resistance.Veterinary research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper examines the known immunological and genetic factors associated with sheep resistance to infection by Haemonchus contortus. Such resistance is an inheritable genetic trait (h(2), 0.22-0.63) associated with certain sheep breeds. Resistant sheep do not completely reject the disease; they only harbor fewer parasites than susceptible sheep and therefore have a lower fecal egg count. Protective immune response to haemonchosis is an expression of genetic resistance. Genes associated with resistance and susceptibility are described. Genetically resistant sheep have nonspecific mechanisms that block the initial colonization by Haemonchus contortus larvae. These sheep also have an efficacious Th2 type response (e.g., increases in blood and tissue eosinophils, specific IgE class antibodies, mast cells, IL-5, IL-13, and TNFα) that protects them against the infection; in contrast, susceptible sheep do not efficiently establish this type of immune response. Finally, the main reported antigens of H. contortus were reviewed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.