ArticleProceedings of the National Academy of Sciences of the United States of America2013
Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 156 citations in OpenAlex.
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- Identification of a novel pegivirus in reindeer (Rangifer tarandus valentinae) in Northeastern China.BMC veterinary research · 2025Article
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- The Blood Virome: A new frontier in biomedical science.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024Review
- Detection of Equine Parvovirus-Hepatitis Virus and Equine Hepacivirus in Archived Sera from Horses in France and Australia.Viruses · 2024Article
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- Description of an Equine Hepacivirus Cluster in a Horse Stable in Italy.Transboundary and emerging diseases · 2023Article
- Nasal transmission of equine parvovirus hepatitis.Journal of veterinary internal medicine · 2022Article
- The Second Human Pegivirus, a Non-Pathogenic RNA Virus with Low Prevalence and Minimal Genetic Diversity.Viruses · 2022Review
- Active equine parvovirus-hepatitis infection is most frequently detected in Austrian horses of advanced age.Equine veterinary journal · 2022Article
- Human Pegivirus Type 1: A Common Human Virus That Is Beneficial in Immune-Mediated Disease?Frontiers in immunology · 2022Review
- Meta-transcriptomic analysis of the virome and microbiome of the invasive Indian myna (One health (Amsterdam, Netherlands) · 2021Article
- Exploring the Diversity of the Human Blood Virome.Viruses · 2021Article
- Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea.Veterinary sciences · 2021Article
- Article
- Equine parvovirus hepatitis.Equine veterinary journal · 2021Review
19 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Theiler's disease is an acute hepatitis in horses that is associated with the administration of equine blood products; its etiologic agent has remained unknown for nearly a century. Here, we used massively parallel sequencing to explore samples from a recent Theiler's disease outbreak. Metatranscriptomic analysis of the short sequence reads identified a 10.5-kb sequence from a previously undescribed virus of the Flaviviridae family, which we designate "Theiler's disease-associated virus" (TDAV). Phylogenetic analysis clusters TDAV with GB viruses of the recently proposed Pegivirus genus, although it shares only 35.3% amino acid identity with its closest relative, GB virus D. An epidemiological survey of additional horses from three separate locations supports an association between TDAV infection and acute serum hepatitis. Experimental inoculation of horses with TDAV-positive plasma provides evidence that several weeks of viremia preceded liver injury and that liver disease may not be directly related to the level of viremia. Like hepatitis C virus, the best characterized Flaviviridae species known to cause hepatitis, we find TDAV is capable of efficient parenteral transmission, engendering acute and chronic infections associated with a diversity of clinical presentations ranging from subclinical infection to clinical hepatitis.
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