ArticleProceedings of the National Academy of Sciences of the United States of America2013
Time-lapse electrical recordings of single neurons from the mouse neocortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Connectivity of single neurons classifies cell subtypes in mouse brains.Nature methods · 2025Article
- Linking brain activity across scales with simultaneous opto- and electrophysiology.Neurophotonics · 2024Review
- Learning in a sensory cortical microstimulation task is associated with elevated representational stability.Nature communications · 2023Article
- Neuronal Connectivity as a Determinant of Cell Types and Subtypes.Research square · 2023Article
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- Article
- Review
- Quantifying How Staining Methods Bias Measurements of Neuron Morphologies.Frontiers in neuroinformatics · 2019Article
- Plasticity of population coding in primary sensory cortex.Current opinion in neurobiology · 2018Review
- A robot for high yield electrophysiology and morphology of single neurons in vivo.Nature communications · 2017Article
- Variance and invariance of neuronal long-term representations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- 3D Image-Guided Automatic Pipette Positioning for Single Cell Experiments in vivo.Scientific reports · 2015Article
- Plasticity during motherhood: changes in excitatory and inhibitory layer 2/3 neurons in auditory cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Recording, labeling, and transfection of single neurons in deep brain structures.Physiological reports · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of the brain to adapt to environmental demands implies that neurons can change throughout life. The extent to which single neurons actually change remains largely unstudied, however. To evaluate how functional properties of single neurons change over time, we devised a way to perform in vivo time-lapse electrophysiological recordings from the exact same neuron. We monitored the contralateral and ipsilateral sensory-evoked spiking activity of individual L2/3 neurons from the somatosensory cortex of mice. At the end of the first recording session, we electroporated the neuron with a DNA plasmid to drive GFP expression. Then, 2 wk later, we visually guided a recording electrode in vivo to the GFP-expressing neuron for the second time. We found that contralateral and ipsilateral evoked responses (i.e., probability to respond, latency, and preference), and spontaneous activity of individual L2/3 pyramidal neurons are stable under control conditions, but that this stability could be rapidly disrupted. Contralateral whisker deprivation induced robust changes in sensory-evoked response profiles of single neurons. Our experiments provide a framework for studying the stability and plasticity of single neurons over long time scales using electrophysiology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.