ArticleInfection and immunity2013
ZnuD, a potential candidate for a simple and universal Neisseria meningitidis vaccine.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Nutritional immunity: the battle for nutrient metals at the host-pathogen interface.Nature reviews. Microbiology · 2022Review
- TonB-dependent receptor epitopes expressed in M. bovis BCG induced significant protection in the hamster model of leptospirosis.Applied microbiology and biotechnology · 2022Article
- Heat shock enhances outer-membrane vesicle release inCurrent research in microbial sciences · 2021Article
- Facing the challenges of multidrug-resistantHuman vaccines & immunotherapeutics · 2021Article
- Zinc is an important inter-kingdom signal between the host and microbe.Veterinary research · 2021Review
- Zinc: Multidimensional Effects on Living Organisms.Biomedicines · 2021Review
- Recent advances in understanding and combattingFaculty reviews · 2021Review
- Metal-Limited Growth of Neisseria gonorrhoeae for Characterization of Metal-Responsive Genes and Metal Acquisition from Host Ligands.Journal of visualized experiments : JoVE · 2020Article
- Hybrid Antigens Expressing Surface Loops of ZnuD FromFrontiers in immunology · 2020Article
- The Acinetobacter baumannii Znu System Overcomes Host-Imposed Nutrient Zinc Limitation.Infection and immunity · 2019Article
- Nutrient Zinc at the Host-Pathogen Interface.Trends in biochemical sciences · 2019Review
- The novel interaction between Neisseria gonorrhoeae TdfJ and human S100A7 allows gonococci to subvert host zinc restriction.PLoS pathogens · 2019Article
- Metal homeostasis and resistance in bacteria.Nature reviews. Microbiology · 2017Review
- The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD.Nature communications · 2015Article
- Metal limitation and toxicity at the interface between host and pathogen.FEMS microbiology reviews · 2014Review
- Zinc piracy as a mechanism of Neisseria meningitidis for evasion of nutritional immunity.PLoS pathogens · 2013Article
- Competition for zinc binding in the host-pathogen interaction.Frontiers in cellular and infection microbiology · 2013Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neisseria meningitidis serogroup B (MenB) is a major cause of bacterial sepsis and meningitis, with the highest disease burden in young children. Available vaccines are based on outer membrane vesicles (OMVs) obtained from wild-type strains. However, particularly in toddlers and infants, they confer protection mostly against strains expressing the homologous protein PorA, a major and variable outer membrane protein. In the quest for alternative vaccine antigens able to provide broad MenB strain coverage in younger populations, but potentially also across all age groups, ZnuD, a protein expressed under zinc-limiting conditions, may be considered a promising candidate. Here, we have investigated the potential value of ZnuD and show that it is a conserved antigen expressed by all MenB strains tested except for some strains of clonal complex ST-8. In mice and guinea pigs immunized with ZnuD-expressing OMVs, antibodies were elicited that were able to trigger complement-mediated killing of all the MenB strains and serogroup A, C, and Y strains tested when grown under conditions of zinc limitation. ZnuD is also expressed during infection, since anti-ZnuD antibodies were detected in sera from patients. In conclusion, we confirm the potential of ZnuD-bearing OMVs as a component of an effective MenB vaccine.
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