ArticleCirculation2013
Ideal cardiovascular health is inversely associated with incident cancer: the Atherosclerosis Risk In Communities study.
Article in Circulation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03935282 (Assessing Effectiveness and Implementation of an EHR Tool to Assess Heart Health Among Survivors), which is not on this map. Cited by 176 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessing Effectiveness and Implementation of an EHR Tool to Assess Heart Health Among Survivors (AH-HA)
Who cites it
176 citing papers in PubMed, 8 syntheses or guidelines pooled it, 306 citations in OpenAlex.
- American Heart Association cardiovascular health metrics and cancer outcomes: A systematic review and meta-analysis.American heart journal · 2026Pooled it
- Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.Journal of the American Heart Association · 2025Pooled it
- Lifestyle scores and their potential to estimate the risk of multiple non-communicable disease-related endpoints: a systematic review.BMC public health · 2025Pooled it
- Pooled it
- Lifestyle Quality Indices and Female Breast Cancer Risk: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Pooled it
- Cardiovascular Disease and Breast Cancer: Where These Entities Intersect: A Scientific Statement From the American Heart Association.Circulation · 2018Pooled it
- Aspirin and the Primary Prevention of Cardiovascular Diseases: An Approach Based on Individualized, Integrated Estimation of Risk.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017Guideline
- Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health.Circulation research · 2021Trial
- A Comprehensive Lifestyle Randomized Clinical Trial: Design and Initial Patient Experience.Integrative cancer therapies · 2017Trial
- Cardiovascular Health and Incident Cardiovascular Disease and Cancer: The Women's Health Initiative.American journal of preventive medicine · 2016Trial
- Article
- Dual-trajectories of Systolic Blood Pressure and Modified Life's Essential 8 With Gastrointestinal Cancer and All-Cause Mortality: A Prospective Cohort Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Construction of an explainable machine learning model based on SHAP for predicting cardiovascular mortality risk among American cancer survivors.Discover oncology · 2026Article
- Lifestyle Medicine and Cardiovascular Health.American journal of lifestyle medicine · 2026Review
- Article
- Prevalence, Determinants, and Time Trends of Cardiovascular Health in the WHO African Region.JAMA cardiology · 2025Article
- Racial and ethnic disparities in childhood cardiovascular health: evidence of the role of social disadvantage from NHANES 2013-2018.BMC medicine · 2025Article
- Elucidating the causal triad of cardiovascular disease, cancer, and lipid traits: a bidirectional Mendelian randomization study with genetic mediation analysis.Discover oncology · 2025Article
- Cardiovascular Health Changes in Young Adults and Risk of Later-Life Cardiovascular Disease.JAMA network open · 2025Article
116 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe American Heart Association (AHA) has defined the concept of ideal cardiovascular health in promotion of the 2020 Strategic Impact Goals. We examined whether adherence to ideal levels of the 7 AHA cardiovascular health metrics was associated with incident cancers in the Atherosclerosis Risk In Communities (ARIC) study over 17 to 19 years of follow-up. METHODS AND
resultsAfter exclusions for missing data and prevalent cancer, 13 253 ARIC participants were included for analysis. Baseline measurements were used to classify participants according to 7 AHA cardiovascular health metrics. Combined cancer incidence (excluding nonmelanoma skin cancers) from 1987 to 2006 was captured using cancer registries and hospital surveillance; 2880 incident cancer cases occurred over follow-up. Cox regression was used to calculate hazard ratios for incident cancer. There was a significant (P trend <0.0001), graded, inverse association between the number of ideal cardiovascular health metrics at baseline and cancer incidence. Participants meeting goals for 6 to 7 ideal health metrics (2.7% of the population) had 51% lower risk of incident cancer than those meeting goals for 0 ideal health metrics. When smoking was removed from the sum of ideal health metrics, the association was attenuated with participants meeting goals for 5 to 6 health metrics having 25% lower cancer risk than those meeting goals for 0 ideal health metrics (P trend =0.03).
conclusionsAdherence to the 7 ideal health metrics defined in the AHA 2020 goals is associated with lower cancer incidence. The AHA should continue to pursue partnerships with cancer advocacy groups to achieve reductions in chronic disease prevalence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.