Evidence map›Paper›PMID 23508980›Full record

ArticleDigestive diseases and sciences2013

Interobserver agreement for the detection of Barrett's esophagus with optical frequency domain imaging.

Jenny Sauk, Emmanuel Coron, Lauren Kava, Melissa Suter, Michalina Gora, Kevin Gallagher, Mireille Rosenberg, Ashwin Ananthakrishnan, Norman Nishioka, Gregory Lauwers and 5 more

Abstract read
In one paragraph

Article in Digestive diseases and sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Screening and Preventive Strategies in Esophagogastric Cancer.Surgical oncology clinics of North America · 2017
    Review
  10. Article
  11. Article
  12. Review
  13. Endoscopic imaging of Barrett's esophagus.World journal of gastrointestinal endoscopy · 2016
    Review
  14. Article
  15. Review
  16. Endoscopic imaging.Current treatment options in gastroenterology · 2015
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jenny SaukWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA. jsauk@partners.org
Emmanuel Coron
Lauren Kava
Melissa Suter
Michalina Gora
Kevin Gallagher
Mireille Rosenberg
Ashwin Ananthakrishnan
Norman Nishioka
Gregory Lauwers
Kevin Woods
William Brugge
David Forcione
Brett E Bouma
Guillermo Tearney

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Improving screening &surveillance in Barrett's patientsR01CA103769 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI TEARNEY, GUILLERMO J · 2003 to 2014
$5.1M
NCI NIH HHS R01 CA103769NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

backgroundOptical frequency domain imaging (OFDI) is a second-generation form of optical coherence tomography (OCT) providing comprehensive cross-sectional views of the distal esophagus at a resolution of ~7 μm.

aimUsing validated OCT criteria for squamous mucosa, gastric cardia mucosa, and Barrett's esophagus (BE), the objective of this study was to determine the inter- and intra-observer agreements by a large number of OFDI readers for differentiating these tissues.

methodsOFDI images were obtained from nine subjects undergoing screening and surveillance for BE. Sixty-four OFDI image regions of interest were randomly selected for review. A training set of 19 images was compiled distinguishing squamous mucosa from gastric cardia and BE using previously validated OCT criteria. The ten readers then interpreted images in a test set of 45 different images of squamous mucosa (n = 15), gastric cardia (n = 15), or BE (n = 15). Interobserver agreement differentiating the three tissue types and BE versus non-BE mucosa was determined using multi-rater Fleiss's κ value. The images were later randomized again and four readers repeated the test 3 weeks later to assess intraobserver reliability.

resultsAll ten readers showed excellent agreement for the differentiation of BE versus non-BE mucosa (κ = 0.811 p < 0.0001) and for differentiating BE versus gastric cardia versus squamous mucosa (κ = 0.866, p < 0.0001). For the four readers who repeated the test, the median intraobserver agreement (BE vs. non-BE) was high (κ = 0.975, IQR: 0.94, 1.0).

conclusionsTrained readers have a high interobserver agreement for differentiating BE, squamous, and gastric cardia mucosa using OFDI.

Indexed as

AgedBarrett EsophagusFemaleHumansMaleMiddle AgedObserver VariationOptical Imaging

Identifiers

PMID23508980
PMCPMC3732518

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.