ArticleFrontiers in oncology2013
Tumor evolution in space: the effects of competition colonization tradeoffs on tumor invasion dynamics.
Article in Frontiers in oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 54 citations in OpenAlex.
- Review
- The Role ofCancers · 2021Review
- Tumour heterogeneity and the evolutionary trade-offs of cancer.Nature reviews. Cancer · 2020Review
- Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer.Molecular cancer · 2019Review
- The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer.Scientific reports · 2019Article
- Review
- After the games are over: life-history trade-offs drive dispersal attenuation following range expansion.Ecology and evolution · 2016Article
- Article
- A multicompartment mathematical model of cancer stem cell-driven tumor growth dynamics.Bulletin of mathematical biology · 2014Article
- Turning ecology and evolution against cancer.Nature reviews. Cancer · 2014Review
- The ecological basis of morphogenesis: branching patterns in swarming colonies of bacteria.New journal of physics · 2014Article
- Life history trade-offs in cancer evolution.Nature reviews. Cancer · 2013Review
- Simulating cancer: computational models in oncology.Frontiers in oncology · 2013Article
- Cancer Community Ecology.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
We apply competition colonization tradeoff models to tumor growth and invasion dynamics to explore the hypothesis that varying selection forces will result in predictable phenotypic differences in cells at the tumor invasive front compared to those in the core. Spatially, ecologically, and evolutionarily explicit partial differential equation models of tumor growth confirm that spatial invasion produces selection pressure for motile phenotypes. The effects of the invasive phenotype on normal adjacent tissue determine the patterns of growth and phenotype distribution. If tumor cells do not destroy their environment, colonizer and competitive phenotypes coexist with the former localized at the invasion front and the latter, to the tumor interior. If tumors cells do destroy their environment, then cell motility is strongly selected resulting in accelerated invasion speed with time. Our results suggest that the widely observed genetic heterogeneity within cancers may not be the stochastic effect of random mutations. Rather, it may be the consequence of predictable variations in environmental selection forces and corresponding phenotypic adaptations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.