ArticleFrontiers in physiology2013
Cytokine-induced oxidative stress in cardiac inflammation and heart failure-how the ubiquitin proteasome system targets this vicious cycle.
Article in Frontiers in physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Vitamin BNutrients · 2019Pooled it
- ATP6AP2 ameliorates inflammation and pyroptosis in heart failure by promoting lysosome-dependent STING degradation.Apoptosis : an international journal on programmed cell death · 2026Article
- Age-Related Shift in Cardiac and Metabolic Phenotyping Linked to Inflammatory Cytokines and Antioxidant Status in Mice.International journal of molecular sciences · 2023Article
- Anti-Inflammatory Klotho Protein Serum Concentration Correlates with Interferon Gamma Expression Related to the Cellular Activity of Both NKT-like and T Cells in the Process of Human Aging.International journal of molecular sciences · 2023Article
- Circulating levels of cytokines and risk of cardiovascular disease: a Mendelian randomization study.Frontiers in immunology · 2023Article
- Circulating Endothelial Progenitor Cells Are Preserved in Female Mice Exposed to Ambient Fine Particulate Matter Independent of Estrogen.International journal of molecular sciences · 2021Article
- Inflammation as a Possible Trigger for Mitoxantrone-Induced Cardiotoxicity: An In Vivo Study in Adult and Infant Mice.Pharmaceuticals (Basel, Switzerland) · 2021Article
- A Comparison Between 1 Day versus 7 Days of Sepsis in Mice with the Experiments on LPS-Activated Macrophages Support the Use of Intravenous Immunoglobulin for Sepsis Attenuation.Journal of inflammation research · 2021Article
- Kidney Ischemia-Reperfusion Decreases Hydrogen Sulfide and Increases Oxidative Stress in the Heart.Biomolecules · 2020Article
- Article
- Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches.European journal of pharmacology · 2018Review
- Effects of a 12-week aerobic exercise on markers of hypertension in men.Journal of cardiovascular and thoracic research · 2018Article
- Inflammation and oxidative stress in heart failure: effects of exercise intensity and duration.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection.PloS one · 2017Article
- Pathobiology of tobacco smoking and neurovascular disorders: untied strings and alternative products.Fluids and barriers of the CNS · 2015Review
- Intermittent or sustained systemic inflammation and the preterm brain.Pediatric research · 2014Review
- Oxidative stress markers and C-reactive protein are related to severity of heart failure in patients with dilated cardiomyopathy.Mediators of inflammation · 2014Article
- Article
- Oxidative stress is predominant in female but not in male patients with autoimmune thrombocytopenia.Oxidative medicine and cellular longevity · 2014Article
- Reductive stress after exercise: The issue of redox individuality.Redox biology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ubiquitin proteasome system (UPS) is critical for the regulation of many intracellular processes necessary for cell function and survival. The absolute requirement of the UPS for the maintenance of protein homeostasis and thereby for the regulation of protein quality control is reflected by the fact that deviation of proteasome function from the norm was reported in cardiovascular pathologies. Inflammation is a major factor contributing to cardiac pathology. Herein, cytokines induce protein translation and the production of free radicals, thereby challenging the cellular protein equilibrium. Here, we discuss current knowledge on the mechanisms of UPS-functional adaptation in response to oxidative stress in cardiac inflammation. The increasing pool of oxidant-damaged degradation-prone proteins in cardiac pathology accounts for the need for enhanced protein turnover by the UPS. This process is accomplished by an up-regulation of the ubiquitylation machinery and the induction of immunoproteasomes. Thereby, the inflamed heart muscle is cleared from accumulating misfolded proteins. Current advances on immunoproteasome-specific inhibitors in this field question the impact of the proteasome as a therapeutic target in heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.