Trial reportClinical oral investigations2014
Concentrations of amoxicillin and clindamycin in teeth following a single dose of oral medication.
Trial report in Clinical oral investigations, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Effects of clindamycin and amoxycillin as prophylaxis against early implant failure: double-blinded randomized clinical trial.Clinical oral investigations · 2024Trial
- A Pilot Study on the Deposition of Drugs in Dental Tissues as Alternative Matrices for Forensic Toxicology.Acta stomatologica Croatica · 2025Article
- In vitro studies on the dependence of drug deposition in dentin on drug concentration, contact time, and the physicochemical properties of the drugs.Archives of toxicology · 2023Article
- Prenatal alcohol exposure can be determined from baby teeth: Proof of concept.Birth defects research · 2022Article
- Is the penetration of clindamycin into the masseter muscle really enough to treat odontogenic infections?Clinical oral investigations · 2021Article
- Minimally Invasive Biospecimen Collection for Exposome Research in Children's Health.Current environmental health reports · 2020Review
- Evaluation of Drug Susceptibility of Microorganisms in Odontogenic Inflammations and Dental Surgery Procedures Performed on an Outpatient Basis.BioMed research international · 2019Article
- The tooth exposome in children's health research.Current opinion in pediatrics · 2016Review
- Tooth matrix analysis for biomonitoring of organic chemical exposure: Current status, challenges, and opportunities.Environmental research · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe main purpose of this study is the detection of amoxicillin and clindamycin concentrations in teeth. MATERIALS AND
methodsEleven patients received 2 g of amoxicillin, and 11 patients received 600 mg of clindamycin in a single dose of oral medication at least 60 min prior to tooth extraction due to systemic diseases. The concentrations were determined in crowns and roots separately using liquid chromatography-tandem mass spectrometry (LC-MS-MS).
resultsAmoxicillin (13 samples) and clindamycin (12 samples) were detected in the samples of the root and crown preparations of the extracted teeth. The mean concentration of amoxicillin was 0.502 μg/g in the roots and 0.171 μg/g in the crowns. The mean concentration of clindamycin was 0.270 μg/g in the roots and 0.064 μg/g in the crowns.
conclusionsA single dose of oral amoxicillin and clindamycin leads to concentrations of both antibiotics in teeth which exceed the minimal inhibition concentration of some oral bacteria. CLINICAL RELEVANCE: The proof of antibacterial activity in dental hard tissue after oral single-dose application is new. The antimicrobial effect of amoxicillin and clindamycin concentrations in roots of teeth may be of clinical relevance to bacterial reinfection from dentinal tubules.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.