ArticleFrontiers in psychiatry2013
Prediction of selective serotonin reuptake inhibitor response using diffusion-weighted MRI.
Article in Frontiers in psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Association between peripheral inflammation and free-water imaging in Major Depressive Disorder before and after ketamine treatment - A pilot study.Journal of affective disorders · 2022Trial
- Serotonin 1A Receptor Binding of [11C]CUMI-101 in Bipolar Depression Quantified Using Positron Emission Tomography: Relationship to Psychopathology and Antidepressant Response.The international journal of neuropsychopharmacology · 2022Trial
- Diffusion Entropy: A Potential Neuroimaging Biomarker of Bipolar Disorder in the Temporal Pole.Synapse (New York, N.Y.) · 2018Trial
- Brain serotonin 1A receptor binding: relationship to peripheral blood DNA methylation, recent life stress and childhood adversity in unmedicated major depression.The British journal of psychiatry : the journal of mental science · 2023Article
- Article
- Structural connectivity and subcellular changes after antidepressant doses of ketamine and Ro 25-6981 in the rat: an MRI and immuno-labeling study.Brain structure & function · 2021Article
- White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression.Frontiers in behavioral neuroscience · 2021Article
- Studying pre-treatment and ketamine-induced changes in white matter microstructure in the context of ketamine's antidepressant effects.Translational psychiatry · 2020Article
- Examining the underpinnings of loudness dependence of auditory evoked potentials with positron emission tomography.NeuroImage · 2020Article
- Examining raphe-amygdala structural connectivity as a biological predictor of SSRI response.Journal of affective disorders · 2019Article
- Molecular connectivity disruptions in males with major depressive disorder.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocolsJournal of psychiatry & neuroscience : JPN · 2019Article
- Cortisol Stress Response and in Vivo PET Imaging of Human Brain Serotonin 1A Receptor Binding.The international journal of neuropsychopharmacology · 2019Article
- Making Sense of Connectivity.The international journal of neuropsychopharmacology · 2019Review
- Development and evaluation of a multimodal marker of major depressive disorder.Human brain mapping · 2018Article
- Kappa opioid receptor binding in major depression: A pilot study.Synapse (New York, N.Y.) · 2018Article
- Relations between cortical thickness, serotonin 1A receptor binding, and structural connectivity: A multimodal imaging study.Human brain mapping · 2018Article
- Neural and Behavioral Predictors of Treatment Efficacy on Mood Symptoms and Cognition in Mood Disorders: A Systematic Review.Frontiers in psychiatry · 2018Article
- The 5-HTTLPR and BDNF polymorphisms moderate the association between uncinate fasciculus connectivity and antidepressants treatment response in major depression.European archives of psychiatry and clinical neuroscience · 2017Article
- Default mode network deactivation during emotion processing predicts early antidepressant response.Translational psychiatry · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Pre-treatment differences in serotonergic binding between those who remit to antidepressant treatment and those who do not have been found using Positron Emission Tomography (PET). To investigate these differences, an exploratory study was performed using a second imaging modality, diffusion-weighted MRI (DW-MRI). Eighteen antidepressant-free subjects with Major Depressive Disorder received a 25-direction DW-MRI scan prior to 8 weeks of selective serotonin reuptake inhibitor treatment. Probabilistic tractography was performed between the midbrain/raphe and two target regions implicated in depression pathophysiology (amygdala and hippocampus). Average fractional anisotropy (FA) within the derived tracts was compared between SSRI remitters and non-remitters, and correlation between pre-treatment FA values and SSRI treatment outcome was assessed. Results indicate that average FA in DW-MRI-derived tracts to the right amygdala was significantly lower in non-remitters (0.55 ± 0.04) than remitters (0.61 ± 0.04, p < 0.01). In addition, there was a significant correlation between average FA in tracts to the right amygdala and SSRI treatment response. These relationships were found at a trend level when using the left amygdala as a tractography target. No significant differences were observed when using the hippocampus as target. These regional differences, consistent with previous PET findings, suggest that the integrity and/or number of white matter fibers terminating in the right amygdala may be compromised in SSRI non-remitters. Further, this study points to the benefits of multimodal imaging and suggests that DW-MRI may provide a pre-treatment signature of SSRI depression remission at 8 weeks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.