ArticleFrontiers in immunology2013
Role of inositol phospholipid signaling in natural killer cell biology.
Article in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway.The Journal of experimental medicine · 2024Article
- Disinfectant dodecyl dimethyl benzyl ammonium chloride (DDBAC) disrupts gut microbiota, phospholipids, and calcium signaling in honeybees (Apis mellifera) at an environmentally relevant level.Environment international · 2022Article
- Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications.Mediators of inflammation · 2022Review
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- Systematic Multiomic Analysis ofJournal of clinical medicine · 2020Article
- Molecular regulation of the plasma membrane-proximal cellular steps involved in NK cell cytolytic function.Journal of cell science · 2020Review
- Myo-inositol in autoimmune thyroiditis, and hypothyroidism.Reviews in endocrine & metabolic disorders · 2018Review
- Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes.Journal of virology · 2016Article
- Review
- Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2015Article
- SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- PTEN is a negative regulator of NK cell cytolytic function.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells.Frontiers in immunology · 2015Review
- Natural Killer Cell Functional Activity After 4-1BB Costimulation.Inflammation · 2015Article
- Article
- Molecular dynamic simulation to explore the molecular basis of Btk-PH domain interaction with Ins(1,3,4,5)P4.TheScientificWorldJournal · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Natural killer (NK) cells are important for host defense against malignancy and infection. At a cellular level NK cells are activated when signals from activating receptors exceed signaling from inhibitory receptors. At a molecular level NK cells undergo an education process to both prevent autoimmunity and acquire lytic capacity. Mouse models have shown important roles for inositol phospholipid signaling in lymphocytes. NK cells from mice with deletion in different members of the inositol phospholipid signaling pathway exhibit defects in development, NK cell repertoire expression and effector function. Here we review the current state of knowledge concerning the function of inositol phospholipid signaling components in NK cell biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.