Evidence map›Paper›PMID 23508266›Full record

ArticleThe pharmacogenomics journal2014

A genome-wide association study of bronchodilator response in asthmatics.

Q L Duan, J Lasky-Su, B E Himes, W Qiu, A A Litonjua, A Damask, R Lazarus, B Klanderman, C G Irvin, S P Peters and 11 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The pharmacogenomics journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00021840 (Genetic Epidemiology of Asthma in Costa Rica), which is not on this map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00021840 completednot on this map

Genetic Epidemiology of Asthma in Costa Rica

TypeobservationalSponsorBrigham and Women's HospitalRan2001 to 2011Enrolled4,245ConditionsAsthma, Lung Diseases
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Pharmacogenetics of Pediatric Asthma: Current Perspectives.Pharmacogenomics and personalized medicine · 2020
    Review
  11. Advances in asthma and allergic disease genetics: Is bigger always better?The Journal of allergy and clinical immunology · 2019
    Review
  12. Article
  13. Heritability and genome-wide associations studies of cerebral blood flow in the general population.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Article
  14. Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma.American journal of respiratory and critical care medicine · 2018
    Article
  15. Article
  16. Article
  17. Asthma Pharmacogenomics: 2015 Update.Current allergy and asthma reports · 2015
    Review
  18. Genetics of allergic diseases.Immunology and allergy clinics of North America · 2015
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 2 countries.

Q L DuanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
J Lasky-SuChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
B E Himes1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Center for Genomic Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
W QiuChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
A A Litonjua1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Pulmonary Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
A DamaskNovartis, Cambridge, MA, USA.
R LazarusChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
B KlandermanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
C G IrvinVermont Lung Center, Department of Medicine and Physiology, University of Vermont, Burlington, Vermont, USA.
S P PetersCenter for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
J P HanrahanPulmatrix, Lexington, MA, USA.
J J LimaNemours Children's Clinic, Centers for Clinical Pediatric Pharmacology and Pharmacogenetics, Jacksonville, FL, USA.
F D MartinezArizona Respiratory Center and BIO5 Institute, University of Arizona, Tucson, AZ, USA.
D MaugerDepartment of Public Health Sciences, Pennsylvania State University, Hershey, PA, USA.
V M ChinchilliDepartment of Public Health Sciences, Pennsylvania State University, Hershey, PA, USA.
M Soto-QuirosHospital Nacional de Niños, San José, Costa Rica.
L AvilaHospital Nacional de Niños, San José, Costa Rica.
J C CeledónDivision of Pediatric Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
C LangeHarvard School of Public Health, Boston, MA, USA.
S T Weiss1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Center for Genomic Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [3] Pulmonary Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [4] Harvard School of Public Health, Boston, MA, USA.
K G Tantisira1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Pulmonary Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USHospital Nacional de Niños · CRPennsylvania State University · USChildren's Hospital of Pittsburgh · USNemours Children’s Clinic · USNovartis (United States) · USPulmatrix (United States) · USUniversity of Arizona · USUniversity of Vermont · USWake Forest University · US

Funding

THE PHARMACOGENETICS OF ASTHMA TREATMENTU01HL065899 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G, WEISS, SCOTT T · 2000 to 2014
$38.5M
ZD1839 FOR MALIGNANT ASTROCYTOMA OR GLIOBLASTOMA AND MENINGIOMAM01RR000079 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$26.0M
ZOSUQUIDAR TRIHYDROCHLORIDE IN NEWLY DIAGNOSED AMLM01RR003186 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI SONDEL, PAUL M · 1986 to 2007
$19.3M
The Genetic Epidemiology of Asthma in Costa RicaR37HL066289 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2015
$14.6M
SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASEST32HL007427 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAWN L DEMEO, Edwin K Silverman · 1985 to 2026
$13.6M
Statistical GeneticsP01HL083069 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2011
$12.2M
Genetics and Gene Expression Profiling in AsthmaR01HL086601 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI RABY, BENJAMIN ALEXANDER · 2007 to 2015
$6.8M
THE GENETIC EPIDEMIOLOGY OF ASTHMA IN COSTA RICAR01HL066289 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2001 to 2005
$5.2M
ASTHMA NETWORK DATA COORDINATING CENTERU10HL051845 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHINCHILLI, VERNON M. · 1993 to 2002
$5.1M
INTEGRATIVE PHARMACOGENOMICS OF LEUKOTRIENE INHIBITION IN ASTHMAR01HL092197 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2009 to 2013
$3.6M
INFORMATIVE STUDIES IN CLINICAL ASTHMAU10HL051831 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT · 1993 to 2002
$2.9M
STEROID AND TARGET CELL FOCUS IN THE TREATMENT OF ASTHMAU10HL051834 · NHLBI · NATIONAL JEWISH HEALTH · PI MARTIN, RICHARD J · 1993 to 2002
$2.3M
NCRR NIH HHS M01 RR000079NCRR NIH HHS M01 RR00079NCRR NIH HHS M01 RR003186NCRR NIH HHS M01RR03186NHGRI NIH HHS K23 HG003983NHLBI NIH HHS HL04370NHLBI NIH HHS HL071394NHLBI NIH HHS HL074755NHLBI NIH HHS HL66289NHLBI NIH HHS HR16045NHLBI NIH HHS HR16046NHLBI NIH HHS HR16047NHLBI NIH HHS HR16048NHLBI NIH HHS HR16049NHLBI NIH HHS HR16050NHLBI NIH HHS HR16051NHLBI NIH HHS HR16052NHLBI NIH HHS K01 HL004370NHLBI NIH HHS N01 HR016044NHLBI NIH HHS N01 HR016045NHLBI NIH HHS N01 HR016046NHLBI NIH HHS N01 HR016047NHLBI NIH HHS N01 HR016048NHLBI NIH HHS N01 HR016049NHLBI NIH HHS N01 HR016050NHLBI NIH HHS N01 HR016051NHLBI NIH HHS N01 HR016052NHLBI NIH HHS N01 HR16044NHLBI NIH HHS N01 HR16049NHLBI NIH HHS P01 HL083069NHLBI NIH HHS R00 HL105663NHLBI NIH HHS R01 HL066289NHLBI NIH HHS R01 HL071394NHLBI NIH HHS R01 HL074755NHLBI NIH HHS R01 HL086601NHLBI NIH HHS R01 HL092197NHLBI NIH HHS R37 HL066289NHLBI NIH HHS T32 HL007427NHLBI NIH HHS T32 HL07427NHLBI NIH HHS U01 HL065899NHLBI NIH HHS U01 HL075419NHLBI NIH HHS U01HL075419NHLBI NIH HHS U01 HL51510NHLBI NIH HHS U01 HL51831NHLBI NIH HHS U01 HL51834NHLBI NIH HHS U01 HL51843NHLBI NIH HHS U01 HL51845NHLBI NIH HHS U01 HL65899NHLBI NIH HHS U10 HL051831NHLBI NIH HHS U10 HL051834NHLBI NIH HHS U10 HL051843NHLBI NIH HHS U10 HL051845
6 · The paper itself

Abstract

Reversibility of airway obstruction in response to β2-agonists is highly variable among asthmatics, which is partially attributed to genetic factors. In a genome-wide association study of acute bronchodilator response (BDR) to inhaled albuterol, 534 290 single-nucleotide polymorphisms (SNPs) were tested in 403 white trios from the Childhood Asthma Management Program using five statistical models to determine the most robust genetic associations. The primary replication phase included 1397 polymorphisms in three asthma trials (pooled n=764). The second replication phase tested 13 SNPs in three additional asthma populations (n=241, n=215 and n=592). An intergenic SNP on chromosome 10, rs11252394, proximal to several excellent biological candidates, significantly replicated (P=1.98 × 10(-7)) in the primary replication trials. An intronic SNP (rs6988229) in the collagen (COL22A1) locus also provided strong replication signals (P=8.51 × 10(-6)). This study applied a robust approach for testing the genetic basis of BDR and identified novel loci associated with this drug response in asthmatics.

Indexed as

Polymorphism, Single NucleotideQuantitative Trait LociAdolescentAdrenergic beta-2 Receptor AgonistsAdultAgedAged, 80 and overAsthmaBronchodilator AgentsChildChild, PreschoolClinical Trials as TopicFemaleGenome-Wide Association StudyHumansMaleAdrenergic beta-2 Receptor AgonistsBronchodilator Agents

Identifiers

PMID23508266
PMCPMC3706515
OpenAlexW2073602941

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.