The why and how of phenotypic small-molecule screens.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

31 citing papers in PubMed.

1. Patient-Derived Conditionally Reprogrammed Cells in Prostate Cancer Research.Cells · 2024
   Review
2. Modeling and Targeting Neuroglial Interactions with Human Pluripotent Stem Cell Models.International journal of molecular sciences · 2022
   Review
3. Natural Products Are a Promising Source for Anthelmintic Drug Discovery.Biomolecules · 2021
   Review
4. Human Pluripotent Stem-Cell-Derived Models as a Missing Link in Drug Discovery and Development.Pharmaceuticals (Basel, Switzerland) · 2021
   Review
5. Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast cancer cells.Oncology letters · 2021
   Article
6. Turning liabilities into opportunities: Off-target based drug repurposing in cancer.Seminars in cancer biology · 2021
   Review
7. Phenotypic Screening inPharmaceuticals (Basel, Switzerland) · 2020
   Review
8. Antileishmanial activity evaluation of thiazolidine-2,4-dione against Leishmania infantum and Leishmania braziliensis.Parasitology research · 2020
   Article
9. Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs.Stem cell reports · 2018
   Article
10. Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box.Chemical science · 2018
    Article
11. Phenotypic Optimization of Urea-Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss.Journal of medicinal chemistry · 2018
    Article
12. LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.Physiological reviews · 2017
    Review
13. Patient-derived induced pluripotent stem cells in cancer research and precision oncology.Nature medicine · 2016
    Article
14. The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine.eLife · 2016
    Article
15. Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-β Type 1 Receptor Kinase Inhibitor Induces Efficient Cardiac Differentiation.Stem cells translational medicine · 2016
    Article
16. Anticancer metallohelices: nanomolar potency and high selectivity.Chemical science · 2016
    Article
17. The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.Cell chemical biology · 2016
    Review
18. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.Nature chemical biology · 2015
    Article
19. Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.Nature reviews. Drug discovery · 2015
    Review
20. Ligand-target prediction by structural network biology using nAnnoLyze.PLoS computational biology · 2015
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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