Evidence map›Paper›PMID 23507925›Full record

ReviewBiomatter

Delivery of EPC embedded in HA-hydrogels for treatment of acute kidney injury.

Brian B Ratliff, Michael S Goligorsky

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomatter. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Brian B RatliffDepartments of Medicine, Pharmacology and Physiology; New York Medical College; Valhalla, NY USA.
Michael S GoligorskyDepartments of Medicine, Pharmacology and Physiology; New York Medical College; Valhalla, NY USA.
New York Medical College · US

Funding

RENAL ENDOTHELIAL AND SMOOTH MUSCLE CELLS INTERACTIONSR01DK045462 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI GOLIGORSKY, MICHAEL S · 1995 to 2014
$4.8M
VASCULAR PERMEABILITY IN DIABETIC NEPHROPATHYR01DK054602 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI GOLIGORSKY, MICHAEL S · 1999 to 2010
$2.5M
Endothelial dysfunction in acute renal ischemiaR01DK052783 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI GOLIGORSKY, MICHAEL S · 1997 to 2007
$2.0M
American Heart Association-American Stroke Association 12SDG9080006NIDDK NIH HHS DK052783NIDDK NIH HHS DK45462NIDDK NIH HHS DK54602NIDDK NIH HHS R01 DK045462NIDDK NIH HHS R01 DK052783NIDDK NIH HHS R01 DK054602
6 · The paper itself

Abstract

Adoptive transfer of stem cells has shown potential as an effective treatment for acute kidney injury (AKI). The current strategy for adoptive transfer of stem cells is by intravenous injection. However, this conventional method of stem cell delivery is riddled with problems causing reduced efficacy of the therapeutic potential of delivered stem cells. This review summarizes the recent advancements in an alternative method of stem cell delivery for treatment of AKI, embedding stem cells in hyaluronic acid (HA-) based hydrogels followed by their implantation. Furthermore, one stem cell type in particular, endothelial progenitor cells (EPC), have shown remarkable therapeutic benefits for treatment of AKI when delivered by HA-hydrogels. The review also summarizes the delivery of EPC by HA-hydrogels in the setting of AKI.

Indexed as

Acute Kidney InjuryAnimalsCell- and Tissue-Based TherapyEndothelial Progenitor CellsHumansHyaluronic AcidHydrogelsTissue EmbeddingTissue ScaffoldsHyaluronic AcidHydrogelsacute kidney injuryAdriamycin-induced kidney injuryendothelial progenitor cellsendotoxemiahyaluronic acid based hydrogelssepsisstem cell therapy

Identifiers

PMID23507925
PMCPMC3732320
OpenAlexW2057084354

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.