ReviewBiomatter
Hyaluronan, neural stem cells and tissue reconstruction after acute ischemic stroke.
Review in Biomatter. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 74 citations in OpenAlex.
- Development and Characterization of Hyaluronic Acid Microgels for Neural Regeneration Applications.Journal of biomedical materials research. Part A · 2025Article
- A step-by-step approach to minimally photothrombotic ischemic stroke in the hippocampal region that simulates human stroke.Lasers in medical science · 2025Article
- Degradation Pattern of a Biodegradable and Photocurable Sealants Based on Hyaluronic Acid : A Serial Magnetic Resonance Imaging Observational Study in Rat Craniectomy Model.Journal of Korean Neurosurgical Society · 2025Article
- Research progress of propofol in alleviating cerebral ischemia/reperfusion injury.Pharmacological reports : PR · 2024Review
- A Promising Application of Injectable Hydrogels in Nerve Repair and Regeneration for Ischemic Stroke.International journal of nanomedicine · 2024Review
- Genetically engineered electrospinning contributes to spinal cord injury repair by regulating the immune microenvironment.Frontiers in bioengineering and biotechnology · 2024Article
- Therapeutic role of neural stem cells in neurological diseases.Frontiers in bioengineering and biotechnology · 2024Review
- The Application of Biomaterials in Spinal Cord Injury.International journal of molecular sciences · 2023Review
- Hyaluronic acid-based bioink improves the differentiation and network formation of neural progenitor cells.Frontiers in bioengineering and biotechnology · 2023Article
- Glycosaminoglycan scaffolding and neural progenitor cell transplantation promotes regenerative immunomodulation in the mouse ischemic brain.Experimental neurology · 2022Article
- Translational Applications of Hydrogels.Chemical reviews · 2021Review
- Technological Advances of 3D Scaffold-Based Stem Cell/Exosome Therapy in Tissues and Organs.Frontiers in cell and developmental biology · 2021Review
- Review
- Cortical Transplantation of Brain-Mimetic Glycosaminoglycan Scaffolds and Neural Progenitor Cells Promotes Vascular Regeneration and Functional Recovery after Ischemic Stroke in Mice.Advanced healthcare materials · 2020Article
- Applying hiPSCs and Biomaterials Towards an Understanding and Treatment of Traumatic Brain Injury.Frontiers in cellular neuroscience · 2020Review
- Neurorestoration Approach by Biomaterials in Ischemic Stroke.Frontiers in neuroscience · 2020Review
- Peptide-modified, hyaluronic acid-based hydrogels as a 3D culture platform for neural stem/progenitor cell engineering.Journal of biomedical materials research. Part A · 2019Article
- A Photoresponsive Hyaluronan Hydrogel Nanocomposite for Dynamic Macrophage Immunomodulation.Advanced healthcare materials · 2019Article
- Human induced pluripotent stem cell-derived mesenchymal stem cell therapy effectively reduced brain infarct volume and preserved neurological function in rat after acute intracranial hemorrhage.American journal of translational research · 2019Article
- Therapeutic neovascularization promoted by injectable hydrogels.Bioactive materials · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Focal stroke is a disabling disease with lifelong sensory, motor and cognitive impairments. Given the paucity of effective clinical treatments, basic scientists are developing novel options for protection of the affected brain and regeneration of lost tissue. Tissue bioengineering and stem/progenitor cell treatments have both been individually pursued for stroke neural repair therapies, with some benefit in tissue recovery. Emerging directions in stroke neural repair approaches combine these two therapies to use biopolymers with stem/progenitor transplants to promote greater cell survival in the transplant and directed delivery of bioactive molecules to the transplanted cells and the adjacent injured tissue. In this review the background literature on a combined use of neural stem/progenitor cells encapsulated in hyaluronan gels is discussed and the way this therapeutic approach can affect the important processes involved in brain tissue reconstruction, such as angiogenesis, axon regeneration, neural differentiation and inflammation is clarified. The glycosaminoglycan hyaluronan can optimize those processes and be employed in a successful neural tissue engineering approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.