ArticleThe Journal of physiology2013
Muscle fibre-type dependence of neuronal nitric oxide synthase-mediated vascular control in the rat during high speed treadmill running.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Human skeletal muscle nitrate store: influence of dietary nitrate supplementation and exercise.The Journal of physiology · 2019Trial
- Acute dietary nitrate supplementation does not augment submaximal forearm exercise hyperemia in healthy young men.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2015Trial
- Lipin1 restores nNOS sarcolemmal localization and improves fatigue resistance in Duchenne muscular dystrophy.American journal of physiology. Cell physiology · 2026Article
- Blue plaque review series: A.V. Hill, athletic records and the birth of exercise physiology.The Journal of physiology · 2025Article
- nNOS Increases Fiber Type-Specific Angiogenesis in Skeletal Muscle of Mice in Response to Endurance Exercise.International journal of molecular sciences · 2023Article
- Nitrite Concentration in the Striated Muscles Is Reversely Related to Myoglobin and Mitochondrial Proteins Content in Rats.International journal of molecular sciences · 2022Article
- Does sympathetic vasoconstriction contribute to metabolism: Perfusion matching in exercising skeletal muscle?Frontiers in physiology · 2022Review
- Influence of muscular contraction on vascular conductance during exercise above versus below critical power.Respiratory physiology & neurobiology · 2021Article
- Vascular ATP-sensitive KThe Journal of physiology · 2020Article
- Nitric oxide synthase inhibition with N(G)-monomethyl-l-arginine: Determining the window of effect in the human vasculature.Nitric oxide : biology and chemistry · 2020Article
- The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Guidelines for animal exercise and training protocols for cardiovascular studies.American journal of physiology. Heart and circulatory physiology · 2020Review
- Repeated Sprint Training in Hypoxia: Case Report of Performance Benefits in a Professional Cyclist.Frontiers in sports and active living · 2020Article
- Edward F. Adolph Distinguished Lecture. Contemporary model of muscle microcirculation: gateway to function and dysfunction.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Review
- Central and peripheral factors mechanistically linked to exercise intolerance in heart failure with reduced ejection fraction.American journal of physiology. Heart and circulatory physiology · 2019Article
- Neuronal nitric oxide synthase regulation of skeletal muscle functional hyperemia: exercise training and moderate compensated heart failure.Nitric oxide : biology and chemistry · 2018Article
- Vasoconstrictor responsiveness in contracting human muscle: influence of contraction frequency, contractile work, and metabolic rate.European journal of applied physiology · 2017Article
- Critical Power: An Important Fatigue Threshold in Exercise Physiology.Medicine and science in sports and exercise · 2016Review
- Regulation of exercise blood flow: Role of free radicals.Free radical biology & medicine · 2016Review
- Skeletal myofiber VEGF regulates contraction-induced perfusion and exercise capacity but not muscle capillarity in adult mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We have recently shown that nitric oxide (NO) derived from neuronal NO synthase (nNOS) does not contribute to the hyperaemic response within rat hindlimb skeletal muscle during low-speed treadmill running. This may be attributed to low exercise intensities recruiting primarily oxidative muscle and that vascular effects of nNOS-derived NO are manifest principally within glycolytic muscle. We tested the hypothesis that selective nNOS inhibition via S-methyl-l-thiocitrulline (SMTC) would reduce rat hindlimb skeletal muscle blood flow and vascular conductance (VC) during high-speed treadmill running above critical speed (asymptote of the hyperbolic speed versus time-to-exhaustion relationship for high-speed running and an important glycolytic fast-twitch fibre recruitment boundary in the rat) principally within glycolytic fast-twitch muscle. Six rats performed three high-speed treadmill runs to exhaustion to determine critical speed. Subsequently, hindlimb skeletal muscle blood flow (radiolabelled microspheres) and VC (blood flow/mean arterial pressure) were determined during supra-critical speed treadmill running (critical speed + 15%, 52.5 ± 1.3 m min(-1)) before (control) and after selective nNOS inhibition with 0.56 mg kg(-1) SMTC. SMTC reduced total hindlimb skeletal muscle blood flow (control: 241 ± 23, SMTC: 204 ± 13 ml min(-1) (100 g)(-1), P < 0.05) and VC (control: 1.88 ± 0.20, SMTC: 1.48 ± 0.13 ml min(-1) (100 g)(-1) mmHg(-1), P < 0.05) during high-speed running. The relative reductions in blood flow and VC were greater in the highly glycolytic muscles and muscle parts consisting of 100% type IIb+d/x fibres compared to the highly oxidative muscles and muscle parts consisting of 35% type IIb+d/x muscle fibres (P < 0.05). These results extend our understanding of vascular control during exercise by identifying fibre-type-selective peripheral vascular effects of nNOS-derived NO during high-speed treadmill running.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.