Trial reportFertility and sterility2013
Neuroendocrine recovery initiated by cognitive behavioral therapy in women with functional hypothalamic amenorrhea: a randomized, controlled trial.
Trial report in Fertility and sterility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01674426 (Pathogenesis of Functional Hypothalamic Amenorrhea), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pathogenesis of Functional Hypothalamic Amenorrhea
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- 2025 Update to the Female Athlete Triad Coalition Consensus Statement Part 2: Clinical Guidelines for Screening, Diagnosis, Treatment, and Return to Play for Adolescents and Adults.Sports medicine (Auckland, N.Z.) · 2026Guideline
- Predictors of pregnancy and live-birth in couples with unexplained infertility after ovarian stimulation-intrauterine insemination.Fertility and sterility · 2016Trial
- Variation in the diagnosis and management of functional hypothalamic amenorrhea across clinical specialties: A nationwide cross-sectional survey in China.The Journal of international medical research · 2026Article
- 2025 Update to the Female Athlete Triad Coalition Consensus Statement Part 1: State of the Science and Introduction of a New Adolescent Model.Sports medicine (Auckland, N.Z.) · 2026Review
- Pharmacological vs. Non-Pharmacological Treatment in the Management of Relative Energy Deficiency in Sport (REDs): A Systematic Review and Meta-Analysis.Sports (Basel, Switzerland) · 2025Review
- Metabolic and Endocrine Alterations in Underweight and Normal-Weight Women with Functional Hypothalamic Amenorrhea.Journal of clinical medicine · 2025Article
- Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review).International journal of molecular medicine · 2025Review
- Sex Differences in the Neurobiology of Fear and Anxiety.Current topics in behavioral neurosciences · 2025Review
- Reversibility of disturbed pituitary function in pediatric conditions with psychological stressors: implications for clinical practice.Hormones (Athens, Greece) · 2024Review
- Functional Hypothalamic Amenorrhea and Preclinical Cardiovascular Disease.The Journal of clinical endocrinology and metabolism · 2023Article
- Comparison of salivary cortisol levels between women with functional hypothalamic amenorrhea and healthy women: a pilot study.Endocrine · 2023Article
- Functional Hypothalamic Amenorrhea: Recognition and Management of a Challenging Diagnosis.Mayo Clinic proceedings · 2023Review
- Sexual functioning in women with functional hypothalamic amenorrhea: exploring the relevance of an underlying polycystic ovary syndrome (PCOS)-phenotype.Journal of endocrinological investigation · 2023Article
- Low-Dose Estrogens as Neuroendocrine Modulators in Functional Hypothalamic Amenorrhea (FHA): The Putative Triggering of the Positive Feedback Mechanism(s).Biomedicines · 2023Review
- The effects of weight loss-related amenorrhea on women's health and the therapeutic approaches: a narrative review.Annals of translational medicine · 2023Review
- Cognition, Behavior, Sexuality, and Autonomic Responses of Women with Hypothalamic Amenorrhea.Brain sciences · 2022Article
- Functional hypothalamic amenorrhea: Impact on bone and neuropsychiatric outcomes.Frontiers in endocrinology · 2022Review
- Acupuncture for Female Infertility: Discussion on Action Mechanism and Application.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Adaptive, reversible, hypothalamic reproductive suppression: More than functional hypothalamic amenorrhea.Frontiers in endocrinology · 2022Article
- Has Menstruation Disappeared? Functional Hypothalamic Amenorrhea-What Is This Story about?Nutrients · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo determine whether cognitive behavior therapy (CBT), which we had shown in a previous study to restore ovarian function in women with functional hypothalamic amenorrhea (FHA), could also ameliorate hypercortisolemia and improve other neuroendocrine and metabolic concomitants of in FHA.
designRandomized controlled trial.
settingClinical research center at an academic medical university. PATIENT(S): Seventeen women with FHA were randomized either to CBT or observation. INTERVENTION(S): CBT versus observation. MAIN OUTCOME MEASURE(S): Circulatory concentrations of cortisol, leptin, thyroid-stimulating hormone (TSH), total and free thyronine (T(3)), and total and free thyroxine (T(4)) before and immediately after completion of CBT or observation. (Each woman served as her own control.) RESULT(S): Cognitive behavior therapy but not observation reduced cortisol levels in women with FHA. There were no changes in cortisol, leptin, TSH, T(3), or T(4) levels in women randomized to observation. Women treated with CBT showed increased levels of leptin and TSH, but their levels of T(3) and T(4) remained unchanged. CONCLUSION(S): In women with FHA, CBT ameliorated hypercortisolism and improved the neuroendocrine and metabolic concomitants of FHA while observation did not. We conclude that a cognitive, nonpharmacologic approach aimed at alleviating problematic attitudes not only can restore ovarian activity but also improve neuroendocrine and metabolic function in women with FHA. CLINICAL TRIAL REGISTRATION NUMBER: NCT01674426.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.