ReviewMolecular aspects of medicine
Characteristics of mammalian Rh glycoproteins (SLC42 transporters) and their role in acid-base transport.
Review in Molecular aspects of medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Mutations in ammonia transporter RhBG that impair NHThe Journal of physiology · 2026Article
- Hypoxia-induced RHCG as a key regulator in psoriasis and its modulation by secukinumab.APL bioengineering · 2025Article
- Article
- Cognitive Effects ofPathogens (Basel, Switzerland) · 2024Article
- Article
- The importance of being heterozygote: effects of RHD-genotype-sex interaction on the physical and mental health of a non-clinical population.Scientific reports · 2021Article
- NBCe1-A is required for the renal ammonia and KAmerican journal of physiology. Renal physiology · 2020Article
- Acid-Base Basics.Seminars in nephrology · 2019Review
- Article
- Structural determinants of NH3 and NH4+ transport by mouse Rhbg, a renal Rh glycoprotein.American journal of physiology. Renal physiology · 2016Article
- Acid-Base Homeostasis.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- Mechanisms of ammonia and ammonium transport by rhesus-associated glycoproteins.American journal of physiology. Cell physiology · 2015Article
- Effect of dietary protein restriction on renal ammonia metabolism.American journal of physiology. Renal physiology · 2015Article
- Does aberrant membrane transport contribute to poor outcome in adult acute myeloid leukemia?Frontiers in pharmacology · 2015Article
- Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells.PloS one · 2015Article
- Effects of chronic lithium administration on renal acid excretion in humans and rats.Physiological reports · 2014Article
- An RNA-seq screen of the Drosophila antenna identifies a transporter necessary for ammonia detection.PLoS genetics · 2014Article
- Everything you need to know about distal renal tubular acidosis in autoimmune disease.Rheumatology international · 2014Review
- Antennal-expressed ammonium transporters in the malaria vector mosquito Anopheles gambiae.PloS one · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian Rh glycoproteins belong to the solute transporter family SLC42 and include RhAG, present in red blood cells, and two non-erythroid members RhBG and RhCG that are expressed in various tissues, including kidney, liver, skin and the GI tract. The Rh proteins in the red blood cell form an "Rh complex" made up of one D-subunit, one CE-subunit and two RhAG subunits. The Rh complex has a well-known antigenic effect but also contributes to the stability of the red cell membrane. RhBG and RhCG are related to the NH4(+) transporters of the yeast and bacteria but their exact function is yet to be determined. This review describes the expression and molecular properties of these membrane proteins and their potential role as NH3/NH4(+) and CO2 transporters. The likelihood that these proteins transport gases such as CO2 or NH3 is novel and significant. The review also describes the physiological importance of these proteins and their relevance to human disease.
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