Evidence map›Paper›PMID 23506862›Full record

ReviewMolecular aspects of medicine

The SLC2 (GLUT) family of membrane transporters.

Mike Mueckler, Bernard Thorens

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular aspects of medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 679 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
679citing papers in PubMed, 1 pooled it
27.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

679 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,292 citations in OpenAlex.

  1. L-3-[International journal of molecular sciences · 2025
    Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. A Combination ofNutrients · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. A novelLife science alliance · 2026
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article

619 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Mike MuecklerDepartment of Cell Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. mmueckler@wustl.edu
Bernard Thorens
University of Lausanne · CHWashington University in St. Louis · US

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1M
STRUCTURE AND FUNCTION OF THE GLUCOSE TRANSPORTERR01DK043695 · NIDDK · WASHINGTON UNIVERSITY · PI MUECKLER, MIKE M · 1991 to 2010
$2.9M
REGULATION OF PROTEIN TRAFFICKING IN ADIPOCYTESR01DK085110 · NIDDK · WASHINGTON UNIVERSITY · PI MUECKLER, MIKE M · 2010 to 2013
$1.3M
NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK043695NIDDK NIH HHS R01 DK085110PHS HHS R0143695
6 · The paper itself

Abstract

GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human and they are categorized into three classes based on sequence similarity. All GLUTs appear to transport hexoses or polyols when expressed ectopically, but the primary physiological substrates for several of the GLUTs remain uncertain. GLUTs 1-5 are the most thoroughly studied and all have well established roles as glucose and/or fructose transporters in various tissues and cell types. The GLUT proteins are comprised of ∼500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 membrane-spanning domains. In this review we briefly describe the major characteristics of the 14 GLUT family members.

Indexed as

Models, BiologicalModels, MolecularProtein ConformationAmino Acid SequenceBiological TransportGlucose Transport Proteins, FacilitativeHexosesHumansMolecular Sequence DataMolecular StructureMultigene FamilyPolymersProtein Structure, TertiaryGlucose Transport Proteins, FacilitativeHexosesPolymerspolyol

Identifiers

PMID23506862
PMCPMC4104978
OpenAlexW2030324194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.