Evidence map›Paper›PMID 23506860›Full record

ReviewMolecular aspects of medicine

The ABCs of membrane transporters in health and disease (SLC series): introduction.

Matthias A Hediger, Benjamin Clémençon, Robert E Burrier, Elspeth A Bruford

Open access · hybridAbstract readReview
In one paragraph

Review in Molecular aspects of medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 287 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
287citing papers in PubMed, 1 pooled it
20.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

287 citing papers in PubMed, 1 synthesis or guideline pooled it, 682 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. SLC16A6 is a tyrosine transporter for the melanosome.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. SLC11A2 withholds divalent metals fromProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

227 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Matthias A HedigerInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland. matthias.hediger@ibmm.unibe.ch
Benjamin Clémençon
Robert E Burrier
Elspeth A Bruford
European Bioinformatics Institute · GBStemina Biomarker Discovery (United States) · USUniversidad Iberoamericana · DOUniversity of Bern · CH

Funding

The Nomenclature of Human GenesP41HG003345 · NHGRI · UNIVERSITY COLLEGE LONDON · PI BIRNEY, EWAN · 2004 to 2012
$3.4M
NHGRI NIH HHS P41 HG003345
6 · The paper itself

Abstract

The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be found at the HUGO Gene Nomenclature Committee (HGNC) website (see www.genenames.org/genefamilies/SLC). This special issue features mini-reviews for each of these SLC families written by the experts in each field. The existing online resource for solute carriers, the Bioparadigms SLC Tables (www.bioparadigms.org), has been updated and significantly extended with additional information and cross-links to other relevant databases, and the nomenclature used in this database has been validated and approved by the HGNC. In addition, the Bioparadigms SLC Tables functionality has been improved to allow easier access by the scientific community. This introduction includes: an overview of all known SLC and "non-SLC" transporter genes; a list of transporters of water soluble vitamins; a summary of recent progress in the structure determination of transporters (including GLUT1/SLC2A1); roles of transporters in human diseases and roles in drug approval and pharmaceutical perspectives.

Indexed as

Models, MolecularProtein ConformationHumansMembrane Transport ProteinsMultigene FamilyTerminology as TopicVitaminsMembrane Transport ProteinsVitamins

Identifiers

PMID23506860
PMCPMC3853582
OpenAlexW2085008263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.