ArticleBMC microbiology2013
Multilocus characterization and phylogenetic analysis of Leishmania siamensis isolated from autochthonous visceral leishmaniasis cases, southern Thailand.
Article in BMC microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Miltefosine and emerging Leishmania (Mundinia) in Southeast Asia: Molecular insights, therapeutic challenges, and future strategic implementation.PLoS neglected tropical diseases · 2026Review
- Leishmania Infection among HIV-Infected Patients in a Southern Province of Thailand: A Cross-Sectional Study.The American journal of tropical medicine and hygiene · 2024Article
- Sergentomyia khawi: a potential vector for Leishmania and Trypanosoma parasites affecting humans and animals and insecticide resistance status in endemic areas of Songkhla, southern Thailand.Parasites & vectors · 2024Article
- Article
- Heterologous Expression and Characterization of a Full-length Protozoan Nitroreductase from Leishmania orientalis isolate PCM2.Molecular biotechnology · 2023Article
- Identification of a conserved maxicircle and unique minicircles as part of the mitochondrial genome of Leishmania martiniquensis strain PCM3 in Thailand.Parasites & vectors · 2022Article
- Making the Most of Its Short Reads: A Bioinformatics Workflow for Analysing the Short-Read-Only Data ofBiology · 2022Article
- Comparative Draft Genomes ofBiology · 2022Article
- Genome Assembly and Genome Annotation ofJournal of parasitology research · 2022Article
- Taxonomy Revision ofJournal of clinical microbiology · 2021Article
- Total Ortholog Median Matrix as an alternative unsupervised approach for phylogenomics based on evolutionary distance between protein coding genes.Scientific reports · 2021Article
- Prevalence of Genetically ComplexFrontiers in cellular and infection microbiology · 2021Review
- PCR-RFLP analyses of Leishmania species causing cutaneous and mucocutaneous leishmaniasis revealed distribution of genetically complex strains with hybrid and mito-nuclear discordance in Ecuador.PLoS neglected tropical diseases · 2019Article
- Leishmania (Mundinia) orientalis n. sp. (Trypanosomatidae), a parasite from Thailand responsible for localised cutaneous leishmaniasis.Parasites & vectors · 2018Article
- Visceral Leishmaniasis in Traveler to Guyana Caused by Leishmania siamensis, London, UK.Emerging infectious diseases · 2018Article
- Prevalence and risk factors associated with Leishmania infection in Trang Province, southern Thailand.PLoS neglected tropical diseases · 2017Article
- Disseminated Autochthonous Dermal Leishmaniasis Caused byThe American journal of tropical medicine and hygiene · 2017Article
- Leishmaniasis in Thailand: A Review of Causative Agents and Situations.The American journal of tropical medicine and hygiene · 2017Review
- The history of leishmaniasis.Parasites & vectors · 2017Review
- Comparison of LAMP and PCR for molecular mass screening of sand flies for Leishmania martiniquensis infection.Memorias do Instituto Oswaldo Cruz · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
backgroundVisceral leishmaniasis (VL) caused by Leishmania siamensis is an emerging disease continuously reported in six southern provinces of Thailand. To date, the phylogenetic relationships among Leishmania isolates from Thai patients and other Leishmania species are still unclear and the taxonomic diversity needs to be established. In this study, the phylogenetic inference trees were constructed based on four genetic loci (i.e., SSU-rRNA, ITS1, hsp70, and cyt b), using DNA sequences obtained from autochthonous VL patients from southern Thailand and reference sequences of reported Leishmania isolates from other studies deposited in GenBank.
resultsPhylogenetic analyses of hsp70 and cyt b loci supported a clade comprised of L. siamensis isolates, which is independent to the other members in the genus Leishmania. In combination with genetic distance analysis, sequence polymorphisms were observed among L. siamensis isolates and two different lineages could be differentiated, lineages PG and TR. Phylogenetic analysis of the cyt b gene further showed that L. siamensis lineage TR is closely related to L. enrietti, a parasite of guinea pigs.
conclusionThe finding of this study sheds further light on the relationships of L. siamensis, both in intra- and inter-species aspects. This information would be useful for further in-depth studies on the biological properties of this important parasite.
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