ArticleAddiction biology2014
Rat ultrasonic vocalizations demonstrate that the motivation to contextually reinstate cocaine-seeking behavior does not necessarily involve a hedonic response.
Article in Addiction biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Emergence of negative affect as motivation for drug taking in rats chronically self-administering cocaine.Psychopharmacology · 2020Article
- Unpleasant Sound Elicits Negative Emotion and Reinstates Drug Seeking.Molecular neurobiology · 2019Article
- Effects of menthol and its interaction with nicotine-conditioned cue on nicotine-seeking behavior in rats.Psychopharmacology · 2017Article
- Poor sensitization of 50-kHz vocalization response to amphetamine predicts rat susceptibility to self-administration of the drug.Psychopharmacology · 2016Article
- Activation of adenosine A₂A receptors suppresses the emission of pro-social and drug-stimulated 50-kHz ultrasonic vocalizations in rats: possible relevance to reward and motivation.Psychopharmacology · 2016Article
- Involvement of Glutamate NMDA Receptors in the Acute, Long-Term, and Conditioned Effects of Amphetamine on Rat 50 kHz Ultrasonic Vocalizations.The international journal of neuropsychopharmacology · 2015Article
- Critical involvement of 5-HT2C receptor function in amphetamine-induced 50-kHz ultrasonic vocalizations in rats.Psychopharmacology · 2015Article
- Ultrasonic Vocalizations as a Measure of Affect in Preclinical Models of Drug Abuse: A Review of Current Findings.Current neuropharmacology · 2015Review
- Environmental and Pharmacological Modulation of Amphetamine- Induced 50-kHz Ultrasonic Vocalizations in Rats.Current neuropharmacology · 2015Review
- Automated detection of 50-kHz ultrasonic vocalizations using template matching in XBAT.Journal of neuroscience methods · 2014Article
- Ultrasonic vocalizations: evidence for an affective opponent process during cocaine self-administration.Psychopharmacology · 2014Article
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8 authors.
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Abstract
Human self-reports often indicate that changes in mood are a major contributor to drug relapse. Still, arguments have been made that instances of drug-seeking following abstinence in animal models (i.e. relapse/reinstatement) may be outside of hedonic control. Therefore, the present study utilized ultrasonic vocalizations in the rat in order to evaluate affect during cocaine self-administration and contextual reinstatement of cocaine-seeking in a pre-clinical model of drug relapse (abstinence-reinstatement model). Results show that while subjects effectively reinstated drug-seeking (lever pressing) following 30 days of abstinence, and spontaneously recovered/reinstated drug-seeking following 60 days of abstinence, ultrasonic vocalizations did not increase over baseline levels during either reinstatement session. These results are consistent with previous results from our laboratory and current theories of addiction suggesting that cues that are weakly associated with drug consumption can motivate drug-seeking behavior that is outside of hedonic processing.
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