ArticleMediterranean journal of hematology and infectious diseases2013
Factors predicting severe dengue in patients with dengue Fever.
Article in Mediterranean journal of hematology and infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Trial
- Article
- Association of Hematological and Biochemical Parameters with Serological Markers of Acute Dengue Infection during the 2022 Dengue Outbreak in Nepal.Journal of tropical medicine · 2023Article
- Severe Thrombocytopenia Associated with Dengue Fever: An Evidence-Based Approach to Management of Thrombocytopenia.Case reports in hematology · 2022Article
- Article
- Determining Risk Factors for Dengue Fever Severity in Jeddah City, a Case-Control Study (2017).Polish journal of microbiology · 2020Article
- Clinical Indicators of Fatal Dengue in Two Endemic Areas of Colombia: A Hospital-Based Case-Control Study.The American journal of tropical medicine and hygiene · 2019Article
- Dengue Outbreaks in Khyber Pakhtunkhwa (KPK), Pakistan in 2017: An Integrated Disease Surveillance and Response System (IDSRS)-Based Report.Polish journal of microbiology · 2019Article
- Predicting the severity of dengue fever in children on admission based on clinical features and laboratory indicators: application of classification tree analysis.BMC pediatrics · 2018Article
- An Evidence-Based Algorithm for Early Prognosis of Severe Dengue in the Outpatient Setting.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Mathematical Modelling of Immune Parameters in the Evolution of Severe Dengue.Computational and mathematical methods in medicine · 2017Article
- Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators.Mediators of inflammation · 2015Review
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDengue virus (DENV) affects over half the world's population in 112 countries, and dengue fever (DF) is the second largest arthropod borne infectious global hazard after malaria with complications like Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS), accounting for significant morbidity and mortality world-over. Pakistan is significantly affected with DENV infection and to-date no study identifying risk factors associated with development of severe complications of DF has been done.
methods997 confirmed cases of DF were collected from a tertiary care hospital in Lahore, Pakistan and their clinical and biochemical data were collected. Univariate, multivariate and logistics regression analysis was performed to identify risk factors associated with development of DHF and DSS.
resultsBleeding OR 70.7 (CI 38.4-129.9), deranged liver function test OR 1.9 (CI 0.97-0.99), presence of urinary red blood cells OR 1.4 (95%CI 0.179-0.900) and presence of urinary protein OR 1.1 (95%CI 0.191-0.974) were related to development of DHF and DSS. DISCUSSION: Severe Dengue, like DHF and DSS can be predicted by the presence of clinical and biochemical factors like signs of bleeding, deranged liver function test, presence of urinary red blood cells and urinary protein; so that the patients at high risk for complication be identified early and started on treatment timely.
conclusionPredictors of severe dengue are identified in this study but further large scale multi-centered studies are needed for better interpretation.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.