ArticleMediterranean journal of hematology and infectious diseases2013
A prospective study of brucellosis in children: relative frequency of pancytopenia.
Article in Mediterranean journal of hematology and infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Frequency of Human Brucellosis Complications in West Asia: A Systematic Review and Meta-Analysis.MicrobiologyOpen · 2026Pooled it
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- A case report of hemophagocytic syndrome induced byFrontiers in immunology · 2025Article
- Article
- The Role of Neutrophils in Brucellosis.Microbiology and molecular biology reviews : MMBR · 2020Review
- Article
- Epidemiologic, clinical, and laboratory characteristics of childhood brucellosis : A study in an Iranian children's referral hospital.Wiener medizinische Wochenschrift (1946) · 2019Article
- Neutrophils Dampen Adaptive Immunity in Brucellosis.Infection and immunity · 2019Article
- Epidemiological, Risk Factors, Clinical, and Laboratory Features of Brucellosis in the Southwest of Iran within 2009-2015.International journal of preventive medicine · 2019Article
- Persistence ofJournal of immunology research · 2018Article
- Pattern of childhood brucellosis in Najran, south Saudi Arabia in 2013-2017.Electronic physician · 2017Article
- Relationship between CD14-159C/T gene polymorphism and acute brucellosis risk.Asian Pacific journal of tropical medicine · 2016Article
- Brucellosis Suspicion is the Most Important Criterion for Diagnosis Particularly in Endemic Regions.The open orthopaedics journal · 2016Article
- Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide.PLoS pathogens · 2015Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledHematological complications in brucellosis are common. Pancytopenia, although mainly reported in adults has also been described in children with brucellosis. This investigation was conducted to estimate the relative frequency of pancytopenia in children with brucellosis. The current study was conducted in Al-Khafji joint operation hospital, Saudi Arabia. Sixty patients with brucellosis, were enrolled in the study. Complete blood count (CBC) and blood culture were performed for all cases. Bone marrow (BM) aspiration was considered only in those with pancytopenia. Out of 60 children with brucellosis, 50 (83%) ingested raw animal milk and 27 (45%) had a positive family history of brucellosis. The common presenting symptoms and signs included excessive sweating (68%), bone aches (62%), chills (55%), arthritis (32%), hepatomegaly (18%), and splenomegaly (15%). The main hematological manifestations included anemia (43%), leukopenia (38%) and leukocytosis (20%). Pancytopenia was detected in 11 patients (18%). Blood culture for Brucella was positive in 38% (23 patients). B.melitensis from 21 patients was cultured in vitro. Out of 9 BM aspirate cultures, 3 were positive for B. melitensis. Out of 11 patients with pancytopenia, 9 (82%) patients had bone aches and weakness, 7 (64%) patients had sweating and chills, and 6 (55%) patients had petechiea and purpura.
conclusionThe current study concludes that although pancytopenia is an uncommon complication of brucellosis in children, it does occur. Therefore, brucellosis should be considered in the differential diagnosis of pancytopenia in children, particularly in endemic areas such as Saudi Arabia.
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