ArticlePLoS neglected tropical diseases2013
Neurocysticercosis: HP10 antigen detection is useful for the follow-up of the severe patients.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 69 citations in OpenAlex.
- Effect of different management strategies on outcomes in subarachnoid neurocysticercosis: a descriptive, multicentre, retrospective cohort study in the USA.EClinicalMedicine · 2026Article
- Repair capacity ofFuture microbiology · 2025Article
- Concomitant Parenchymal, Subarachnoid, and Ventricular Neurocysticercosis in Rome, Italy: A Case Report with a 4-Year Follow-Up.Tropical medicine and infectious disease · 2024Article
- Subarachnoid Neurocysticercosis Case Series Reveals a Significant Delay in Diagnosis-Requiring a High Index of Suspicion Among Those at Risk.Open forum infectious diseases · 2024Article
- From laboratory to clinical practice: an update of the immunological and molecular tools for neurocysticercosis diagnosis.Frontiers in parasitology · 2024Review
- A recombinant monoclonal-based Taenia antigen assay that reflects disease activity in extra-parenchymal neurocysticercosis.PLoS neglected tropical diseases · 2022Article
- Demand forFrontiers in veterinary science · 2021Article
- Neurocysticercosis: Current Perspectives on Diagnosis and Management.Frontiers in veterinary science · 2021Review
- Subarachnoid neurocysticercosis: emerging concepts and treatment.Current opinion in infectious diseases · 2020Review
- A Novel, Highly Sensitive Quantitative Polymerase Chain Reaction Assay for the Diagnosis of Subarachnoid and Ventricular Neurocysticercosis and for Assessing Responses to Treatment.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Optimal Treatment for Subarachnoid Neurocysticercosis: Closer, but Not There yet.The American journal of tropical medicine and hygiene · 2020Article
- Natural History of Treated Subarachnoid Neurocysticercosis.The American journal of tropical medicine and hygiene · 2020Article
- Monitoring treatment of Taenia solium- neurocysticercosis by detection of circulating antigens: a case report.BMC neurology · 2019Article
- Neurocysticercosis in Pregnancy.AJP reports · 2018Article
- The HP10 Taenia monoclonal antibody-based ELISA detects a similar protein in the vesicular fluid of Taenia hydatigena.Tropical animal health and production · 2018Article
- Present status of laboratory diagnosis of human taeniosis/cysticercosis in Europe.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Review
- Comparison of T24H-his, GST-T24H and GST-Ts8B2 recombinant antigens in western blot, ELISA and multiplex bead-based assay for diagnosis of neurocysticercosis.Parasites & vectors · 2017Article
- Taenia solium cysticercosis and taeniosis: Achievements from the past 10 years and the way forward.PLoS neglected tropical diseases · 2017Article
- Update on the Diagnosis and Management of Neurocysticercosis.Current infectious disease reports · 2016Review
- Neurocysticercosis in Bhutan: a cross-sectional study in people with epilepsy.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe most severe clinical form of neurocysticercosis (NC) occurs when cysticerci are located in the subarachnoid space at the base of the brain (SaB). The diagnosis, monitoring and treatment of NC-SaB, constitutes a severe clinical challenge. Herein we evaluate the potential of the HP10 antigen detection enzyme-linked immunosorbent assay (HP10 Ag-ELISA) in the long term follow-up of NC-SaB cases. Assay performance was compared with that of Magnetic Resonance Imaging (MRI). In addition, the robustness of the HP10 Ag-ELISA was evaluated independently at two different institutions. METHODOLOGY/PRINCIPAL
findingsA double-blind prospective cohort trial was conducted involving 38 NC-SaB cases and a total of 108 paired serum and cerebrospinal fluid (CSF) samples taken at intervals of 4 to 8 months for up to 43 months. At each medical visit, results of sera and CSF HP10 Ag-ELISA and MRI obtained at last visit were compared and their accuracy was evaluated retrospectively, considering radiological evolution between appointments. In the long-term follow-up study, HP10 Ag-ELISA had a better agreement than MRI with retrospective radiological evaluation. High reproducibility of HP10 Ag-ELISA between laboratories was also demonstrated.
conclusionsResults reported in this study establish for the first time the usefulness of the comparatively low cost HP10 Ag-ELISA for long term follow-up of NC-SaB patients.
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