ArticlePLoS neglected tropical diseases2013
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Effects of Schistosoma haematobium infection and treatment on the systemic and mucosal immune phenotype, gene expression and microbiome: A systematic review.PLoS neglected tropical diseases · 2024Pooled it
- Multi-dimensional analysis of B cells reveals the expansion of memory and regulatory B-cell clusters in humans living in rural tropical areas.Clinical and experimental immunology · 2025Article
- Pediatric B cell repertoires are enriched for naive clonal phenotypes and are shaped by distinct selection dynamics.Frontiers in immunology · 2025Article
- Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses.PLoS pathogens · 2022Article
- Schistosome immunomodulators.PLoS pathogens · 2021Review
- Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Immunological and Biochemical Interplay between Cytokines, Oxidative Stress and Schistosomiasis.International journal of molecular sciences · 2021Review
- Transcriptome and IgH Repertoire Analyses Show That CD11cFrontiers in immunology · 2021Observational
- Worms: Pernicious parasites or allies against allergies?Parasite immunology · 2019Review
- Wuchereria bancrofti-infected individuals harbor distinct IL-10-producing regulatory B and T cell subsets which are affected by anti-filarial treatment.PLoS neglected tropical diseases · 2019Article
- Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells.PLoS pathogens · 2017Article
- Interferon-driven deletion of antiviral B cells at the onset of chronic infection.Science immunology · 2016Article
- Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment.PLoS pathogens · 2016Article
- CD23 can negatively regulate B-cell receptor signaling.Scientific reports · 2016Article
- Subversion of the B-cell compartment during parasitic, bacterial, and viral infections.BMC immunology · 2015Review
- B-cell subpopulations in children: National reference values.Immunity, inflammation and disease · 2014Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulation in Gabonese schoolchildren with Schistosoma haematobium infection. Frequencies of memory B cell (MBC) subsets were increased, whereas naive B cell frequencies were reduced in the schistosome-infected group. At the functional level, isolated B cells from schistosome-infected children showed higher expression of the activation marker CD23 upon stimulation, but lower proliferation and TNF-α production. Importantly, 6-months after 3 rounds of praziquantel treatment, frequencies of naive B cells were increased, MBC frequencies were decreased and with the exception of TNF-α production, B cell responsiveness was restored to what was seen in uninfected children. These data show that S. haematobium infection leads to significant changes in the B cell compartment, both at the phenotypic and functional level.
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