ArticlePloS one2013
Decreased IL-7 responsiveness is related to oxidative stress in HIV disease.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Oxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution?Health science reports · 2025Review
- Genotoxic consequences of viral infections.Npj viruses · 2025Review
- Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up Study.International journal of molecular sciences · 2022Observational
- Influenza A Virus Uses PSMA2 for Downregulation of the NRF2-Mediated Oxidative Stress Response.Journal of virology · 2022Article
- Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis.Annals of medicine · 2021Review
- Review
- Dysfunctional Immunometabolism in HIV Infection: Contributing Factors and Implications for Age-Related Comorbid Diseases.Current HIV/AIDS reports · 2020Review
- The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity.Nature immunology · 2020Article
- Therapeutic Modulation of Virus-Induced Oxidative Stress via the Nrf2-Dependent Antioxidative Pathway.Oxidative medicine and cellular longevity · 2018Review
- Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection.Journal of virology · 2016Article
- Reactive Oxygen Species in HIV Infection.EC microbiology · 2016Article
- Oxidative Stress during HIV Infection: Mechanisms and Consequences.Oxidative medicine and cellular longevity · 2016Review
- Recycled IL-7 Can Be Delivered to Neighboring T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells.PLoS pathogens · 2014Article
- Cycling memory CD4+ T cells in HIV disease have a diverse T cell receptor repertoire and a phenotype consistent with bystander activation.Journal of virology · 2014Article
- Redox regulation of Janus kinase: The elephant in the room.JAK-STAT · 2013Review
- Residual immune dysregulation syndrome in treated HIV infection.Advances in immunology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
HIV disease results in decreased IL-7 receptor expression and IL-7 responsiveness in T cells. To explore mechanisms of these deficiencies, we compared CD127 expression and IL-7 induction of P-STAT5 in T cells from HIV-infected persons with serum concentrations of cytokines (IL-7, IL-6 and IL-15), markers of microbial translocation (sCD14 and LPS), and with an indicator of oxidative stress (malondialdehyde (MDA) adducts). CD127 expression was directly related to IL-7 responsiveness in most CD8+ T cell subsets but not in CD4+ T cells from HIV-infected persons. MDA adducts were increased in serum of HIV-infected patients and were inversely related to IL-7 responsiveness in CD8+ T cells and in central memory CD4+ T cells. Incubation of T cells from healthy controls with hydrogen peroxide resulted in impairments in IL-7 induction of P-STAT5. These findings suggest that oxidative stress that is characteristic of HIV disease could contribute to impairments in IL-7 responsiveness and disrupt T cell homeostasis.
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Registered trials
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