ArticlePloS one2013
Subpopulations of Staphylococcus aureus clonal complex 121 are associated with distinct clinical entities.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 45 citations in OpenAlex.
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- An unusual outbreak in the Netherlands: community-onset impetigo caused by a meticillin-resistantEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022Observational
- Survey of Staphylococcus aureus carriage by free-living red deer (Cervus elaphus): Evidence of human and domestic animal lineages.Transboundary and emerging diseases · 2022Article
- Differences in virulence between the two more prevalent Staphylococcus aureus clonal complexes in rabbitries (CC121 and CC96) using an experimental model of mammary gland infection.Veterinary research · 2020Article
- Phenotypic and Molecular Characteristics of Community-AssociatedInfection and drug resistance · 2020Article
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- Epidemiological studies based on multi-locus sequence typing genotype of methicillin susceptibleThe Onderstepoort journal of veterinary research · 2017Article
- Emergence of a Staphylococcus aureus Clone Resistant to Mupirocin and Fusidic Acid Carrying Exotoxin Genes and Causing Mainly Skin Infections.Journal of clinical microbiology · 2017Article
- Evolution of themBio · 2017Article
- Omics Approaches for the Study of Adaptive Immunity toProteomes · 2016Review
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- Outbreak of Panton-Valentine Leukocidin-Associated Methicillin-Susceptible Staphylococcus aureus Infection in a Rugby Team, France, 2010-2011.Emerging infectious diseases · 2016Article
- A single natural nucleotide mutation alters bacterial pathogen host tropism.Nature genetics · 2015Article
- ClonalFrameML: efficient inference of recombination in whole bacterial genomes.PLoS computational biology · 2015Article
- Clinical and molecular epidemiology of community-onset invasive Staphylococcus aureus infection in New Zealand children.Epidemiology and infection · 2014Article
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Authors and funding
18 authors at 10 institutions in 9 countries.
Funding
Abstract
We investigated the population structure of Staphylococcus aureus clonal complex CC121 by mutation discovery at 115 genetic housekeeping loci from each of 154 isolates, sampled on five continents between 1953 and 2009. In addition, we pyro-sequenced the genomes from ten representative isolates. The genome-wide SNPs that were ascertained revealed the evolutionary history of CC121, indicating at least six major clades (A to F) within the clonal complex and dating its most recent common ancestor to the pre-antibiotic era. The toxin gene complement of CC121 isolates was correlated with their SNP-based phylogeny. Moreover, we found a highly significant association of clinical phenotypes with phylogenetic affiliations, which is unusual for S. aureus. All isolates evidently sampled from superficial infections (including staphylococcal scalded skin syndrome, bullous impetigo, exfoliative dermatitis, conjunctivitis) clustered in clade F, which included the European epidemic fusidic-acid resistant impetigo clone (EEFIC). In comparison, isolates from deep-seated infections (abscess, furuncle, pyomyositis, necrotizing pneumonia) were disseminated in several clades, but not in clade F. Our results demonstrate that phylogenetic lineages with distinct clinical properties exist within an S. aureus clonal complex, and that SNPs serve as powerful discriminatory markers, able to identify these lineages. All CC121 genomes harboured a 41-kilobase prophage that was dissimilar to S. aureus phages sequenced previously. Community-associated MRSA and MSSA from Cambodia were extremely closely related, suggesting this MRSA arose in the region.
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