ArticlePloS one2013
Cellular effects of curcumin on Plasmodium falciparum include disruption of microtubules.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Antimalarial efficacy ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Article
- Curcumin ameliorates chronicIranian journal of basic medical sciences · 2023Article
- Antiproliferative Effects of Curcumin Different Types of Breast Cancer.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Piperine Enhances the Antimalarial Activity of Curcumin inEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Effects of Curcumin and Its Analogues on Infectious Diseases.Advances in experimental medicine and biology · 2021Review
- Oral Therapy Using a Combination of Nanotized Antimalarials and Immunomodulatory Molecules Reduces Inflammation and Prevents Parasite Induced Pathology in the Brain and Spleen ofFrontiers in immunology · 2021Article
- The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review.Journal of tropical medicine · 2021Review
- Cytotoxic and Anti-Plasmodial Activities ofMolecules (Basel, Switzerland) · 2020Article
- Enhanced uptake, high selective and microtubule disrupting activity of carbohydrate fused pyrano-pyranones derived from natural coumarins attributes to its anti-malarial potential.Malaria journal · 2019Article
- Retention of Anticancer Activity of Curcumin after Conjugation with Fluorescent Gold Quantum Clusters: An in Vitro and in Vivo Xenograft Study.ACS omega · 2018Article
- Functionalization of β-lactam antibiotic on lysozyme capped gold nanoclusters retrogress MRSA and its persisters following awakening.Scientific reports · 2018Article
- Antimalarial evaluation of selected medicinal plant extracts used in Iranian traditional medicine.Iranian journal of basic medical sciences · 2017Article
- Membrane and luminal proteins reach the apicoplast by different trafficking pathways in the malaria parasitePeerJ · 2017Article
- The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.Molecules (Basel, Switzerland) · 2016Review
- Short peptide based nanotubes capable of effective curcumin delivery for treating drug resistant malaria.Journal of nanobiotechnology · 2016Article
- Garcinol Inhibits GCN5-Mediated Lysine Acetyltransferase Activity and Prevents Replication of the Parasite Toxoplasma gondii.Antimicrobial agents and chemotherapy · 2016Article
- Small molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5.The Journal of biological chemistry · 2014Article
- In vitro study of parasite elimination and endothelial protection by curcumin: adjunctive therapy for cerebral malaria.EXCLI journal · 2014Article
- Article
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5 authors.
Funding
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Abstract
Curcumin has been widely investigated for its myriad cellular effects resulting in reduced proliferation of various eukaryotic cells including cancer cells and the human malaria parasite Plasmodium falciparum. Studies with human cancer cell lines HT-29, Caco-2, and MCF-7 suggest that curcumin can bind to tubulin and induce alterations in microtubule structure. Based on this finding, we investigated whether curcumin has any effect on P. falciparum microtubules, considering that mammalian and parasite tubulin are 83% identical. IC50 of curcumin was found to be 5 µM as compared to 20 µM reported before. Immunofluorescence images of parasites treated with 5 or 20 µM curcumin showed a concentration-dependent effect on parasite microtubules resulting in diffuse staining contrasting with the discrete hemispindles and subpellicular microtubules observed in untreated parasites. The effect on P. falciparum microtubules was evident only in the second cycle for both concentrations tested. This diffuse pattern of tubulin fluorescence in curcumin treated parasites was similar to the effect of a microtubule destabilizing drug vinblastine on P. falciparum. Molecular docking predicted the binding site of curcumin at the interface of alpha and beta tubulin, similar to another destabilizing drug colchicine. Data from predicted drug binding is supported by results from drug combination assays showing antagonistic interactions between curcumin and colchicine, sharing a similar binding site, and additive/synergistic interactions of curcumin with paclitaxel and vinblastine, having different binding sites. This evidence suggests that cellular effects of curcumin are at least, in part, due to its perturbing effect on P. falciparum microtubules. The action of curcumin, both direct and indirect, on P. falciparum microtubules is discussed.
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