ArticlePLoS computational biology2013
Collective cell motion in an epithelial sheet can be quantitatively described by a stochastic interacting particle model.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
- Partial EMT Drives Persistent Collective Migration via Collision Guidance in Heterogeneous Populations.bioRxiv : the preprint server for biology · 2026Article
- Measurement of tissue viscosity to relate force and motion in collective cell migration.Soft matter · 2026Article
- Partial fluidization theory of collective cell migration.Communications physics · 2026Article
- Local activation of Cxcl12a signaling controls olfactory placode morphogenesis in zebrafish embryos.iScience · 2025Article
- Vertex model with internal dissipation enables sustained flows.Nature communications · 2025Article
- Confinement, Jamming, and Adhesion in Cancer Cells Dissociating from a Collectively Invading Strand.PRX life · 2025Article
- Cell-Level Modelling of Homeostasis in Confined Epithelial Monolayers.Journal Of Elasticity · 2025Article
- Article
- [The Dynamic Model of the Active-Inactive Cell Interface].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Polarization and motility of one-dimensional multi-cellular trains.Biophysical journal · 2023Article
- Non-reciprocity across scales in active mixtures.Nature communications · 2023Article
- Effective mechanical potential of cell-cell interaction explains three-dimensional morphologies during early embryogenesis.PLoS computational biology · 2023Article
- A hybrid physics-based and data-driven framework for cellular biological systems: Application to the morphogenesis of organoids.iScience · 2023Article
- Curvature induces active velocity waves in rotating spherical tissues.Nature communications · 2023Article
- A computational framework for testing hypotheses of the minimal mechanical requirements for cell aggregation using early annual killifish embryogenesis as a model.Frontiers in cell and developmental biology · 2023Article
- Learning mean-field equations from particle data using WSINDy.Physica D. Nonlinear phenomena · 2022Article
- Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration.Biophysical journal · 2022Article
- Topological data analysis of collective and individual epithelial cells using persistent homology of loops.Soft matter · 2021Article
- Article
- Learning the dynamics of cell-cell interactions in confined cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modelling the displacement of thousands of cells that move in a collective way is required for the simulation and the theoretical analysis of various biological processes. Here, we tackle this question in the controlled setting where the motion of Madin-Darby Canine Kidney (MDCK) cells in a confluent epithelium is triggered by the unmasking of free surface. We develop a simple model in which cells are described as point particles with a dynamic based on the two premises that, first, cells move in a stochastic manner and, second, tend to adapt their motion to that of their neighbors. Detailed comparison to experimental data show that the model provides a quantitatively accurate description of cell motion in the epithelium bulk at early times. In addition, inclusion of model "leader" cells with modified characteristics, accounts for the digitated shape of the interface which develops over the subsequent hours, providing that leader cells invade free surface more easily than other cells and coordinate their motion with their followers. The previously-described progression of the epithelium border is reproduced by the model and quantitatively explained.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.