ArticleJournal of medical genetics2013
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
Article in Journal of medical genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 5 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis.Scientific reports · 2021Pooled it
- ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.Nature communications · 2019Pooled it
- The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies.Translational psychiatry · 2017Pooled it
- Investigation of associations between ten polymorphisms and the risk of coronary artery disease in Southern Han Chinese.Journal of human genetics · 2016Pooled it
- Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.Scientific reports · 2016Pooled it
- Trial
- Influence of tissue context on gene prioritization for predicted transcriptome-wide association studies.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2019Trial
- Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202.Pharmacogenetics and genomics · 2017Trial
- Lessons from single cell omics: admixed American ancestry and sex confer cardiometabolic disease risk in Mexicans.Genome medicine · 2026Article
- Pathway-Based Genetic Risk Scores Are Associated with Blood Lipids Among Young Mexican Adults.Nutrients · 2026Article
- Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure.Nature communications · 2025Article
- Admixture Mapping of Lipid Traits in Hispanic Americans.Journal of the American Heart Association · 2025Article
- Fine-mapping in admixed populations using CARMA-X, with applications to Latin American studies.American journal of human genetics · 2025Article
- Mitoregulin, a tiny protein at the crossroads of mitochondrial functioning, stress, and disease.Frontiers in cell and developmental biology · 2025Review
- Characterisation and Hypolipidaemic Effects of Tlayudas, Widely Consumed Tortillas, ContainingInternational journal of food science · 2025Article
- Metabolic syndrome in children and adolescents: definitions, epidemiology, pathophysiology, interventions, and challenges.Frontiers in endocrinology · 2025Review
- Interaction between genetic risk score and dietary fat intake on lipid-related traits in Brazilian young adults.The British journal of nutrition · 2024Article
- Selection scan in Native Americans of Mexico identifiesHeliyon · 2024Article
- Article
- Genetic Determinants of Atherogenic Indexes.Genes · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe Mexican population and others with Amerindian heritage exhibit a substantial predisposition to dyslipidemias and coronary heart disease. Yet, these populations remain underinvestigated by genomic studies, and to date, no genome-wide association (GWA) studies have been reported for lipids in these rapidly expanding populations. METHODS AND
findingsWe performed a two-stage GWA study for hypertriglyceridemia and low high-density lipoprotein cholesterol (HDL-C) in Mexicans (n=4361), and identified a novel Mexican-specific genome-wide significant locus for serum triglycerides (TGs) near the Niemann-Pick type C1 protein gene (p=2.43×10(-08)). Furthermore, three European loci for TGs (APOA5, GCKR and LPL), and four loci for HDL-C (ABCA1, CETP, LIPC and LOC55908) reached genome-wide significance in Mexicans. We used cross-ethnic mapping to narrow three European TG GWA loci, APOA5, MLXIPL, and CILP2 that were wide and contained multiple candidate variants in the European scan. At the APOA5 locus, this reduced the most likely susceptibility variants to one, rs964184. Importantly, our functional analysis demonstrated a direct link between rs964184 and postprandial serum apoAV protein levels, supporting rs964184 as the causative variant underlying the European and Mexican GWA signal. Overall, 52 of the 100 reported associations from European lipid GWA meta-analysis generalised to Mexicans. However, in 82 of the 100 European GWA loci, a different variant other than the European lead/best-proxy variant had the strongest regional evidence of association in Mexicans.
conclusionsThis first Mexican GWA study of lipids identified a novel GWA locus for high TG levels; used the interpopulation heterogeneity to significantly restrict three previously known European GWA signals, and surveyed whether the European lipid GWA SNPs extend to the Mexican population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.