ArticleObesity (Silver Spring, Md.)2013
Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans.
Article in Obesity (Silver Spring, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 29 citations in OpenAlex.
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- Identification of a 5-Gene Metabolic Signature for Predicting Prognosis Based on an Integrated Analysis of Tumor Microenvironment in Lung Adenocarcinoma.Journal of oncology · 2020Article
- The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders.PLoS genetics · 2020Article
- Genome-wide scan reveals genetic divergence and diverse adaptive selection in Chinese local cattle.BMC genomics · 2019Article
- MEF2A Regulates the MEG3-DIO3 miRNA Mega Cluster-Targeted PP2A Signaling in Bovine Skeletal Myoblast Differentiation.International journal of molecular sciences · 2019Article
- Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis.Cellular and molecular gastroenterology and hepatology · 2019Article
- The impact of genetic variants on BMI increase during childhood versus adulthood.International journal of obesity (2005) · 2016Article
- Context Specific and Differential Gene Co-expression Networks via Bayesian Biclustering.PLoS computational biology · 2016Article
- Transcriptome profile of liver at different physiological stages reveals potential mode for lipid metabolism in laying hens.BMC genomics · 2015Article
- Colorectal cancer screening among American Indians in a Pacific Northwest tribe: Cowlitz Tribal BRFSS Project, 2009-2010.Public health reports (Washington, D.C. : 1974) · 2014Article
- Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
objectiveA genome-wide association study (GWAS) was recently completed in 1120 Pima Indians to identify loci that influence BMI. Among the top 100 signals were three variants that mapped within the lysophosphatidylglycerol acyltransferase 1 (LPGAT1) gene. LPGAT1 belongs to a large family of acyltransferases, which are involved in a variety of biological processes including pathways that regulate energy homeostasis and body weight. Therefore LPGAT1 was analyzed as a candidate gene for obesity in Pima Indians. DESIGN AND
methodsVariants (n = 26) located within and adjacent to LPGAT1 including a novel 27bp deletion in the 5'-untranslated region identified by sequencing were genotyped in a population-based sample of 3,391 full-heritage Pima Indians living in the Gila River Indian Community. Replication of selected variants was assessed in a second sample of 3,327 mixed-heritage Native Americans from the same community.
resultsVariants with nominal associations with BMI in each of the two independent samples (tagged by rs112662024 and rs12058008) had associations of P = 1-4 × 10(-5) in the combined sample (n = 6718). A haplotype that includes the novel 27bp deletion, which does not occur in Caucasians, showed the strongest association with BMI in the full-heritage Pima Indians. In vitro functional studies provided suggestive evidence that this 27bp deletion may affect transcriptional or posttranscriptional regulation. Analysis of LPGAT1 cDNA from human preadipocytes identified an additional exon whose sequence could potentially serve as a mitochondrial targeting peptide.
conclusionsLPGAT1 is a novel gene that influences BMI in Native Americans.
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