ArticleNMR in biomedicine2013
31P NMR relaxation of cortical bone mineral at multiple magnetic field strengths and levels of demineralization.
Article in NMR in biomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- A CombinedAnnals of biomedical engineering · 2026Article
- Using solid-state MRI and a double-tuned RF coil to quantify bone matrix and mineral densities in rat bones.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025Article
- QuantitativeBone · 2024Article
- Unraveling Water-MediatedACS omega · 2022Article
- In vivo boneMagnetic resonance in medicine · 2018Article
- Article
- Solid-stateScientific reports · 2017Article
- Feasibility of assessing bone matrix and mineral properties in vivo by combined solid-state 1H and 31P MRI.PloS one · 2017Article
- Imaging human teeth by phosphorus magnetic resonance with nuclear Overhauser enhancement.Scientific reports · 2016Article
- Bone and Mineral Metabolism: Where Are We, Where Are We Going, and How Will We Get There?The Journal of clinical endocrinology and metabolism · 2016Article
- A Surrogate Measure of Cortical Bone Matrix Density by Long T2 -Suppressed MRI.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Bone mineral (31)P and matrix-bound water densities measured by solid-state (31)P and (1)H MRI.NMR in biomedicine · 2014Article
- Correction of excitation profile in Zero Echo Time (ZTE) imaging using quadratic phase-modulated RF pulse excitation and iterative reconstruction.IEEE transactions on medical imaging · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Recent work has shown that solid-state (1) H and (31) P MRI can provide detailed insight into bone matrix and mineral properties, thereby potentially enabling differentiation of osteoporosis from osteomalacia. However, (31) P MRI of bone mineral is hampered by unfavorable relaxation properties. Hence, accurate knowledge of these properties is critical to optimizing MRI of bone phosphorus. In this work, (31) P MRI signal-to-noise ratio (SNR) was predicted on the basis of T1 and T2 * (effective transverse relaxation time) measured in lamb bone at six field strengths (1.5-11.7 T) and subsequently verified by 3D ultra-short echo-time and zero echo-time imaging. Further, T1 was measured in deuterium-exchanged bone and partially demineralized bone. (31) P T2 * was found to decrease from 220.3 ± 4.3 µs to 98.0 ± 1.4 µs from 1.5 to 11.7 T, and T1 to increase from 12.8 ± 0.5 s to 97.3 ± 6.4 s. Deuteron substitution of exchangeable water showed that 76% of the (31) P longitudinal relaxation rate is due to (1) H-(31) P dipolar interactions. Lastly, hypomineralization was found to decrease T1, which may have implications for (31) P MRI based mineralization density quantification. Despite the steep decrease in the T2 */T1 ratio, SNR should increase with field strength as B0 (0.4) for sample-dominated noise and as B0 (1.1) for coil-dominated noise. This was confirmed by imaging experiments.
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Registered trials
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