Evidence map›Paper›PMID 23504765›Full record

ArticleCurrent cardiovascular imaging reports2013

Molecular MRI of the Cardiovascular System in the Post-NSF Era.

David E Sosnovik, Peter Caravan

Abstract read
In one paragraph

Article in Current cardiovascular imaging reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

David E SosnovikMartinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA ; Department of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston MA ; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston MA.
Peter Caravan

Funding

Stable, High Relaxivity MRI Contrast AgentsR01EB009062 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2009 to 2017
$4.9M
Molecular and Microstructural Imaging of Cardiomyocyte Apoptosis and AutophagyR01HL093038 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SOSNOVIK, DAVID E · 2008 to 2012
$2.2M
NHLBI NIH HHS R01 HL093038NIBIB NIH HHS R01 EB009062
6 · The paper itself

Abstract

Two new molecular MRI agents have been approved for clinical use within the last 3 years, and a third agent has completed phase-2 clinical trials. A wealth of preclinical data is also emerging on the general safety of many molecular MR imaging agents. In addition, since the guidelines to avoid nephrogenic systemic fibrosis (NSF) were adopted, at most institutions no new cases of NSF have been reported. Nevertheless, in the post-NSF environment, both those developing and using molecular MR imaging agents need to be increasingly aware of safety issues. This awareness should begin with the design of the agent and, even in early preclinical studies, the demonstration of safety and efficacy should both be given high priority. In this review we discuss some of the issues relevant to the design of safe molecular MR imaging agents and highlight the excellent safety profile of those agents that have been used clinically to date.

Indexed as

CardiovascularGadoliniumIron OxideMolecular ImagingMRISafety

Identifiers

PMID23504765
PMCPMC3597126

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.