ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2013
The vasovagal response of the rat: its relation to the vestibulosympathetic reflex and to Mayer waves.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04976101 (A Pilot Study to Assess Sinusoidal Galvanic Vestibular Stimulation in Neurogenic Orthostatic Hypotension), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study to Assess Sinusoidal Galvanic Vestibular Stimulation in Neurogenic Orthostatic Hypotension
Who cites it
17 citing papers in PubMed.
- Intravenous administration of a selective metabotropic glutamate receptor 2/3 agonist attenuates hypertension in spontaneously hypertensive rats.The Journal of veterinary medical science · 2026Article
- Hemodynamic Response to Air-Conducted Sound Stimulus Is Mediated via Vestibulosympathetic Reflex.Journal of clinical medicine · 2025Article
- The vestibular system in pain and embodiment: cortical overlap, modulatory potential, and therapeutic perspectives.Frontiers in neuroscience · 2025Article
- Using macular velocity measurements to relate parameters of bone conduction to vestibular compound action potential responses.Scientific reports · 2023Article
- Pulsed Infrared Stimulation of Vertical Semicircular Canals Evokes Cardiovascular Changes in the Rat.Frontiers in neurology · 2021Article
- Predicting Vasovagal Responses: A Model-Based and Machine Learning Approach.Frontiers in neurology · 2021Article
- The Scientific Contributions of Bernard Cohen (1929-2019).Frontiers in neurology · 2020Review
- Vestibular, locomotor, and vestibulo-autonomic research: 50 years of collaboration with Bernard Cohen.Journal of neurophysiology · 2020Review
- Low-intensity ultrasound activates vestibular otolith organs through acoustic radiation force.The Journal of the Acoustical Society of America · 2017Article
- Vestibular Modulation of Sympathetic Nerve Activity to Muscle and Skin in Humans.Frontiers in neurology · 2017Review
- Vestibular Activation Habituates the Vasovagal Response in the Rat.Frontiers in neurology · 2017Article
- The response of the vestibulosympathetic reflex to linear acceleration in the rat.Journal of neurophysiology · 2016Article
- Imidazoleacetic acid-ribotide in vestibulo-sympathetic pathway neurons.Experimental brain research · 2016Article
- A Model of Blood Pressure, Heart Rate, and Vaso-Vagal Responses Produced by Vestibulo-Sympathetic Activation.Frontiers in neuroscience · 2016Article
- Projection neurons of the vestibulo-sympathetic reflex pathway.The Journal of comparative neurology · 2014Article
- Vestibulo-sympathetic responses.Comprehensive Physiology · 2014Review
- Vasovagal oscillations and vasovagal responses produced by the vestibulo-sympathetic reflex in the rat.Frontiers in neurology · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Vasovagal responses (VVRs) are characterized by transient drops in blood pressure (BP) and heart rate (HR) and increased amplitude of low-frequency oscillations in the Mayer wave frequency range. Typical VVRs were induced in anesthetized, male, Long-Evans rats by sinusoidal galvanic vestibular stimulation (sGVS). VVRs were also produced by single sinusoids that transiently increased BP and HR, by 70-90° nose-up tilts, and by 60° tilts of the gravitoinertial acceleration vector using translation while rotating (TWR). The average power of the BP signal in the Mayer wave range increased substantially when tilts were >70° (0.91 g), i.e., when linear accelerations in the x-z plane were ≥0.9-1.0 g. The standard deviations of the wavelet-filtered BP signals during tilt and TWR overlaid when they were normalized to 1 g. Thus, the amplitudes of the Mayer waves coded the magnitude of the linear acceleration ≥1 g acting on the head and body, and the average power in this frequency range was associated with the generation of VVRs. These data show that VVRs are a natural outcome of stimulation of the vestibulosympathetic reflex and are not a disease. The results also demonstrate the usefulness of the rat as a small animal model for studying human VVRs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.