Evidence map›Paper›PMID 23504650›Full record

SynthesisHepatology (Baltimore, Md.)2013

Incidence and prevalence of hepatitis C in prisons and other closed settings: results of a systematic review and meta-analysis.

Sarah Larney, Hannah Kopinski, Curt G Beckwith, Nickolas D Zaller, Don Des Jarlais, Holly Hagan, Josiah D Rich, Brenda J van den Bergh, Louisa Degenhardt

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Hepatology (Baltimore, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 23 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 23 syntheses or guidelines pooled it.

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  5. Stroke in Africa: A systematic review and meta-analysis of the incidence and case-fatality rates.International journal of stroke : official journal of the International Stroke Society · 2023
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  9. Stroke in India: A systematic review of the incidence, prevalence, and case fatality.International journal of stroke : official journal of the International Stroke Society · 2022
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  13. Hepatitis B and C prevalence and incidence in key population groups with multiple risk factors in the EU/EEA: a systematic review.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sarah LarneyNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia; Alpert Medical School, Brown University, Providence, RI, USA.
Hannah Kopinski
Curt G Beckwith
Nickolas D Zaller
Don Des Jarlais
Holly Hagan
Josiah D Rich
Brenda J van den Bergh
Louisa Degenhardt

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
CARE Corrections: Technology for Jail HIV/HCV Testing, Linkage, and Care (TLC)R01DA030747 · NIDA · MIRIAM HOSPITAL · PI BECKWITH, CURT G, KUO, IRENE · 2010 to 2014
$4.9M
Midcareer Investigator Award in Patient Oriented ResearchK24DA022112 · NIDA · MIRIAM HOSPITAL · PI RICH, JOSIAH D · 2008 to 2017
$1.7M
Comprehensive HIV Testing Strategies for JailsK23DA021095 · NIDA · MIRIAM HOSPITAL · PI BECKWITH, CURT G · 2007 to 2011
$779k
NIAID NIH HHS P30 AI042853NIDA NIH HHS K23 DA021095NIDA NIH HHS K24 DA022112NIDA NIH HHS R01 DA030747
6 · The paper itself

Abstract

unlabelledPeople detained in prisons and other closed settings are at elevated risk of infection with hepatitis C virus (HCV). We undertook a systematic review and meta-analysis with the aim of determining the rate of incident HCV infection and the prevalence of anti-HCV among detainees in closed settings. We systematically searched databases of peer-reviewed literature and widely distributed a call for unpublished data. We calculated summary estimates of incidence and prevalence among general population detainees and detainees with a history of injection drug use (IDU), and explored heterogeneity through stratification and meta-regression. The summary prevalence estimates were used to estimate the number of anti-HCV positive prisoners globally. HCV incidence among general detainees was 1.4 per 100 person-years (py; 95% confidence interval [CI]: 0.1, 2.7; k = 4), and 16.4 per 100 py (95% CI: 0.8, 32.1; k = 3) among detainees with a history of IDU. The summary prevalence estimate of anti-HCV in general detainees was 26% (95% CI: 23%, 29%; k = 93), and in detainees with a history of IDU, 64% (95% CI: 58%, 70%; k = 51). The regions of highest prevalence were Central Asia (38%; 95% CI 32%, 43%; k = 1) and Australasia (35%; 95% CI: 28%, 43%; k = 9). We estimate that 2.2 million (range: 1.4-2.9 million) detainees globally are anti-HCV positive, with the largest populations in North America (668,500; range: 553,500-784,000) and East and Southeast Asia (638,000; range: 332,000-970,000).

conclusionHCV is a significant concern in detained populations, with one in four detainees anti-HCV-positive. Epidemiological data on the extent of HCV infection in detained populations is lacking in many countries. Greater attention towards prevention, diagnosis, and treatment of HCV infection among detained populations is urgently required.

Indexed as

Confined SpacesAntibodies, ViralFemaleGlobal HealthHepacivirusHepatitis CHumansIncidenceMalePrevalencePrisonsRetrospective StudiesAntibodies, Viral

Identifiers

PMID23504650
PMCPMC3723697

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.