SynthesisInternational urology and nephrology2013
The role of duloxetine in stress urinary incontinence: a systematic review and meta-analysis.
Synthesis in International urology and nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Evidence evaluation of acupuncture and its related therapies for female urinary incontinence: an overview and quality assessment of systematic reviews and meta-analyses.European journal of physical and rehabilitation medicine · 2024Pooled it
- Effect of Acupuncture for Mixed Urinary Incontinence in Women: A Systematic Review.Frontiers in public health · 2022Pooled it
- Effect of single doses of citalopram and reboxetine on urethral pressure: A randomized, double-blind, placebo- and active-controlled three-period crossover study in healthy women.Neurourology and urodynamics · 2022Trial
- Comparative analysis of male stress urinary incontinence treatments: A review of efficacy, safety, and clinical outcomes.Current urology · 2026Review
- Conservative Treatment in Stress Urinary Incontinence-Narrative Literature Review.Life (Basel, Switzerland) · 2026Review
- A comprehensive review of conservative therapies for female stress urinary incontinence: Advancements, efficacy, and future directions.Current urology · 2025Review
- Prevalence and clinical correlates for depression in women with urinary incontinence: a cross-sectional study.International urogynecology journal · 2022Article
- Chirality of antidepressive drugs: an overview of stereoselectivity.Asian biomedicine : research, reviews and news · 2022Review
- The placebo and nocebo effects in functional urology.Nature reviews. Urology · 2022Review
- Delivery of the 5-HTBiology · 2021Article
- Urinary incontinence associated with anxiety and depression: the impact of psychotropic drugs in a cross-sectional study from the Norwegian HUNT study.BMC psychiatry · 2020Article
- Chirality of Modern Antidepressants: An Overview.Advanced pharmaceutical bulletin · 2017Article
- Urinary incontinence in women.Nature reviews. Disease primers · 2017Review
- Small Molecule Agonists of Cell Adhesion Molecule L1 Mimic L1 Functions In Vivo.Molecular neurobiology · 2016Article
- Predicting New Target Conditions for Drug Retesting Using Temporal Patterns in Clinical Trials: A Proof of Concept.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2015Article
- Mixed incontinence: what takes precedence in its management?Current urology reports · 2014Review
- Regenerative medicine based applications to combat stress urinary incontinence.World journal of stem cells · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis systematic review determined whether the duloxetine can get more benefits versus placebo in managing women with stress urinary incontinence (SUI) all over the world.
methodsWe performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing duloxetine with placebo in these patients. The eligible RCTs were identified from the following electronic databases: Cochrane CENTRAL, Medline and EMBASE. We treated the incontinence episode frequency (IEF) as the main outcome, and the secondary outcomes were cured, average voiding interval, incontinence quality of life (I-QOL), treatment-emergent adverse events (TEAEs) and discontinuation.
resultsThe review contained ten trials including 5,738 women who were randomized to take duloxetine or placebo. All arms in individual trials were comparable for various baseline characteristics. Individual studies showed a significantly greater decrease in IEF than placebo group. The total IEF responders (defined as a woman who had at least a 50 % decrease in IEF with treatment) within the duloxetine-treated women were more than the placebo-treated women (52.5 vs. 33.7 %; RR = 1.56; 95 %CI, 1.46-1.66; p < 0.00001). TEAEs were commonly experienced by both two groups (62.7 vs. 45.3 %) though they were not critical. AUTHORS'
conclusionsOur meta-analysis showed that significant efficacy can be found in women treated with a certain dose of duloxetine. The adverse events like nausea, constipation, dry mouth, fatigue etc. are common.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.