ArticleEuropean journal of organic chemistry2010
A Template-Mediated Click-Click Reaction: PNA-DNA, PNA-PNA (or Peptide) Ligation, and Single Nucleotide Discrimination.
Article in European journal of organic chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- One-pot multi-substrate screening of ligation reactions using PNA tags.Chemical science · 2026Article
- Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications.RSC chemical biology · 2022Review
- Rapid oligonucleotide-templated fluorogenic tetrazine ligations.Nucleic acids research · 2013Article
- Enzyme-free translation of DNA into sequence-defined synthetic polymers structurally unrelated to nucleic acids.Nature chemistry · 2013Article
- Click nucleic acid ligation: applications in biology and nanotechnology.Accounts of chemical research · 2012Review
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A highly efficient chemical ligation was developed for quantitative conjugation of PNA with DNA (PNA or peptide) using the copper-catalyzed azide-alkyne cycloaddition reaction. While PNAs with an alkyne at the C-terminus and an azide at the N-terminus have been used, an efficient click-click reaction occurs. The PNA click ligation is sequence-specific and capable of single nucleotide discrimination.
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Registered trials
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