ArticleInternational journal of bioscience, biochemistry and bioinformatics2012
Relationship of Oxidative Stress with HIV Disease Progression in HIV/HCV Co-infected and HIV Mono-infected Adults in Miami.
Article in International journal of bioscience, biochemistry and bioinformatics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02552602 (The Role of Multivitamins in Pediatric HIV Management in Nigeria), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Multivitamins in Pediatric HIV Management in Nigeria: A Randomized Controlled Study
Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Factors associated with oxidative stress in virologically suppressed people living with HIV on long-term antiretroviral therapy.AIDS research and therapy · 2024Article
- Oral and anal microbiome from HIV-exposed individuals: role of host-associated factors in taxa composition and metabolic pathways.NPJ biofilms and microbiomes · 2023Article
- Time Course of Redox Biomarkers in COVID-19 Pneumonia: Relation with Inflammatory, Multiorgan Impairment Biomarkers and CT Findings.Antioxidants (Basel, Switzerland) · 2021Article
- Susceptibility of the patients infected with Sars-Cov2 to oxidative stress and possible interplay with severity of the disease.Free radical biology & medicine · 2021Article
- Oxidative Stress as a Risk Factor for Hearing Changes in HIV-positive Normal Listeners.Clinics (Sao Paulo, Brazil) · 2020Article
- Mitochondrial electron transport chain, ROS generation and uncoupling (Review).International journal of molecular medicine · 2019Article
- Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression.World journal of gastroenterology · 2019Review
- Low Plasma Zinc Is Associated with Higher Mitochondrial Oxidative Stress and Faster Liver Fibrosis Development in the Miami Adult Studies in HIV Cohort.The Journal of nutrition · 2017Article
- Liver Damage in Patients with HCV/HIV Coinfection Is Linked to HIV-Related Oxidative Stress.Oxidative medicine and cellular longevity · 2016Article
- Effects of treatment on free radicals in patients with pulmonary tuberculosis in South Western Nigeria.African health sciences · 2015Article
- Polycyclic aromatic hydrocarbons and cytochrome P450 in HIV pathogenesis.Frontiers in microbiology · 2015Review
- Reactive oxygen species in health and disease.Journal of biomedicine & biotechnology · 2012Review
- Infection, Oxidative Stress, and Changes in Circulating Regulatory T Cells of Heart Failure Patients Supported by Continuous-Flow Ventricular Assist Devices.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHIV and HCV infections are both characterized by increased oxidative stress. Information on the magnitude of this increase and its consequences in HIV/HCV co-infection and viral replication is limited. We investigated the relationship between oxidative stress and HIV-progression in HIV/HCV co-infected and HIV mono-infected adults.
methods106 HIV/HCV co-infected and 115 HIV mono-infected participants provided demographic information and blood to determine 8-oxo-dG and percent oxidized glutathione.
resultsHIV/HCV co-infected subjects had higher percent oxidized glutathione, higher HIV viral load, lower mtDNA copies and higher liver fibrosis than mono-infected subjects. In a small sample of HIV/HCV co-infected participants with liver biopsy, 8-oxo-dG was significantly lower in participants with low fibrosis scores than those with high fibrosis scores, and the grade of inflammation was strongly associated with oxidized glutathione.
conclusionsHIV/HCV co-infection seems to diminish the capacity of the antioxidant system to control oxidative stress, and increases HIV replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.