Evidence map›Paper›PMID 23504525›Full record

SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2013

Association between the C3435T polymorphism of ABCB1/MDR1 gene (rs1045642) and colorectal cancer susceptibility : a meta-analysis based on 11,339 subjects.

Li Zhao, Kai Li, Wusheng Li, Zhen Yang

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. SMAD7 rs12953717 polymorphism contributes to increased risk of colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. XRCC1 genetic polymorphism acts a potential biomarker for lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Article
  8. Two SNPs of ATP-binding cassette B1 gene on the risk and prognosis of colorectal cancer.International journal of clinical and experimental pathology · 2015
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Li ZhaoDepartment of Oncology, Shengjing Hospital of China Medical University, Shenyang, 110022, China. lizhao_shenyang@163.com
Kai Li
Wusheng Li
Zhen Yang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between ABCB1/MDR1 C3435T polymorphism and colorectal cancer has been evaluated. However, the results of these studies on the association remain inconsistent. To derive a more precise estimation of the relationship, a meta-analysis was performed. A comprehensive search was conducted to identify the eligible studies of ABCB1/MDR1 C3435T polymorphism and colorectal cancer risk. Summary odds ratios (OR) and 95 % confidence interval (CI) for ABCB1/MDR1 C3435T polymorphism and colorectal cancer were calculated. Statistical analysis was performed with the Stata (Version 12.0). Thirteen case-control studies, a total of 11,339 persons including 5,485 cases and 5,854 controls, met the included criteria and thus were selected. Collectively, the results of the present study suggest that there were no significant associations of ABCB1/MDR1 C3435T polymorphism with colorectal cancer observed for all comparison models. In the subgroup analysis, the same results were detected for both Caucasian and Asian populations. The results of this meta-analysis suggest that ABCB1/MDR1 C3435T polymorphism might be not related to colorectal cancer susceptibility.

Indexed as

Genetic Predisposition to DiseaseATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1Case-Control StudiesColorectal NeoplasmsHumansPolymorphism, GeneticRisk FactorsABCB1 protein, humanATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1

Identifiers

PMID23504525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.