Evidence map›Paper›PMID 23504451›Full record

ReviewTranslational stroke research2013

Tolerance to ischemia - an increasingly complex biology.

Robert Meller, Roger P Simon

Abstract readReview
In one paragraph

Review in Translational stroke research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Enhanced Retinal Ganglion Cell Survival in Glaucoma by Hypoxic Postconditioning After Disease Onset.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert MellerNeuroscience Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310-1495 ; Department of Neurobiology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310-1495 ; Department of Pharmacology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310-1495.
Roger P Simon

Funding

Morehouse School of Medicine Center of Excellence Research Endowment ProgramS21MD000101 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MONTGOMERY-RICE, VALERIE C. · 2001 to 2015
$74.3M
TRANSCRIPTION FACTORS AND PROSTATE CANCERG12RR003034 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI ZHAO, XUEYING · 1986 to 2011
$32.4M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Research Desogn and Biostatistics CoreU54MD007588 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MAYBERRY, ROBERT M · 2012 to 2018
$24.8M
WARCEFU54RR026137 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI CONERLY HOLLIDAY, RHONDA C · 2009 to 2011
$14.6M
Training and knowledge transferU54NS060659 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI FORD, BYRON D. · 2008 to 2012
$6.9M
Rapid ischemic tolerance: Synaptic re-organization and reduced excitotoxicityR01NS059588 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI MELLER, ROBERT · 2008 to 2012
$1.6M
MicroRNAs as Molecular Effectors of Seizure-preconditioningR56NS073714 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI SIMON, ROGER PANCOAST · 2011 to 2011
$330k
NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1TR000454NCRR NIH HHS G12 RR003034NCRR NIH HHS G12-RR03034NCRR NIH HHS U54 RR026137NIMHD NIH HHS S21 MD000101NIMHD NIH HHS U54 MD007588NINDS NIH HHS NS59588NINDS NIH HHS R01 NS059588NINDS NIH HHS R56 NS073714NINDS NIH HHS U54 NS060659
6 · The paper itself

Abstract

In this review we identify and discuss some of the genomics studies of preconditioning and the ischemic tolerance phenomenon. Such studies have been attempted in multiple species, using different array technologies and with different preconditioning and tolerance models. In addition, studies are starting to reveal epigenetic mechanisms and modifiers of tolerance and preconditioning. Together these studies are starting to reveal some of the immense complexity of the ischemic tolerance phenomenon, yet further studies await to be performed.

Indexed as

GenomicsIschemic PreconditioningAnimalsBrainBrain IschemiaHumansMiceRats

Identifiers

PMID23504451
PMCPMC3596882

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.