ArticleHuman cell2013
Proteomic analysis of differential protein expression by brain metastases of gynecological malignancies.
Article in Human cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
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- Platelet-derived extracellular vesicles inhibit ferroptosis and promote distant metastasis of nasopharyngeal carcinoma by upregulating ITGB3.International journal of biological sciences · 2022Article
- Systemic Analyses of the Expression of TPI1 and Its Associations with Tumor Microenvironment in Lung Adenocarcinoma and Squamous Cell Carcinoma.Disease markers · 2022Article
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- Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.Journal of hematology & oncology · 2021Article
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- Transgelin-2: A Double-Edged Sword in Immunity and Cancer Metastasis.Frontiers in cell and developmental biology · 2021Review
- Nuclear Enolase-1/ MBP-1 expression and its association with the Wnt signaling in epithelial ovarian cancer.Translational oncology · 2021Article
- Proteomics analysis identified TPI1 as a novel biomarker for predicting recurrence of intrahepatic cholangiocarcinoma.Journal of gastroenterology · 2020Article
- Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and Prognosis.Cancers · 2020Review
- Validation of Androgen Receptor loss as a risk factor for the development of brain metastases from ovarian cancers.Journal of ovarian research · 2020Article
- Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factor‑κB signaling pathway.Molecular medicine reports · 2019Article
- Proteomic profiling identifies outcome-predictive markers in patients with peripheral T-cell lymphoma, not otherwise specified.Blood advances · 2018Article
- TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas.Journal of experimental & clinical cancer research : CR · 2017Article
- Exosomes isolated from cancer patients' sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells.Journal of experimental & clinical cancer research : CR · 2017Article
- Androgen receptor status predicts development of brain metastases in ovarian cancers.Oncotarget · 2017Article
- Advances in decoding breast cancer brain metastasis.Cancer metastasis reviews · 2016Review
- Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients.Journal of experimental & clinical cancer research : CR · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain metastases of gynecological malignancies are rare, but the incidence is increasing. Patients with brain metastases have a poor prognosis, therefore early detection and optimal management is necessary. In order to determine a new biomarker, we aimed to identify proteins that associated with brain metastases. We investigated proteins associated with brain metastases of gynecological malignancies in three patients who underwent surgical resection (stage IIb cervical cancer, stage Ib endometrial cancer, and stage IIIb ovarian cancer). Proteomic analysis was performed on formalin-fixed paraffin-embedded (FFPE) samples of the primary tumors and brain metastases, which were analyzed by liquid chromatography with tandem mass spectrometry. Thereafter, candidate proteins were identified by the Scaffold system and Mascot search program, and were analyzed using western blotting and immunohistochemistry. As a result, a total of 129 proteins were identified. In endometrial and ovarian cancers, western blotting revealed that the expression of alpha-enolase (ENO1) and triosephosphate isomerase (TPI-1) was higher and the expression of Transgelin-2 (TAGLN2) was lower in metastatic tumors than in primary tumors. On the other hand, the expression of TPI-1 and TAGLN2 was lower in metastatic tumors than in primary tumors in cervical cancer. Immunohistochemistry confirmed that ENO1 expression was elevated in the metastatic tumors compared with the primary tumors. In conclusion, the present study showed that FFPE tissue-based proteomics analysis can be powerful tool, and these findings suggested that ENO1, TPI-1, and TAGLN2 may have a role in the development and progression of brain metastasis from gynecological malignancies.
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