Evidence map›Paper›PMID 23504241›Full record

Trial reportPsychosomatic medicine2013

Effect of paroxetine on physiological response to stress and smoking.

Michael Kotlyar, Mustafa al'Absi, Paul Thuras, John P Vuchetich, David E Adson, April L Nowack, Dorothy K Hatsukami

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychosomatic medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00218439 (Smoking, Antidepressants, and Response to Mental Stress), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00218439 nacompletednot on this map

Smoking, Antidepressants, and Response to Mental Stress

TypeinterventionalSponsorUniversity of MinnesotaRan2005 to 2010Enrolled105ConditionsTobacco Use DisorderArmsParoxetine, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Antidepressant Drugs Effects on Blood Pressure.Frontiers in cardiovascular medicine · 2021
    Review
  2. Article
  3. Review
  4. Article
  5. Sex differences in physiological response to the combination of stress and smoking.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michael KotlyarDepartment of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA. kotly001@umn.edu
Mustafa al'Absi
Paul Thuras
John P Vuchetich
David E Adson
April L Nowack
Dorothy K Hatsukami
University of Minnesota · US

Funding

YOUTH DRUG ABUSE, ADHD, AND RELATED DISRUPTIVE DISORDERSM01RR000400 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BACHANOVA, VERONIKA S · 1985 to 2009
$33.7M
Stress Response and Opioid Dysfunction in Nicotine DependenceR01DA016351 · NIDA · UNIVERSITY OF MINNESOTA DULUTH · PI AL'ABSI, MUSTAFA · 2003 to 2023
$4.5M
Smoking, Antidepressants and Response to Mental StressK23DA017307 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI KOTLYAR, MICHAEL · 2005 to 2009
$693k
NCRR NIH HHS M01 RR000400NCRR NIH HHS M01-RR00400NIDA NIH HHS K23 DA017307NIDA NIH HHS K23DA017307NIDA NIH HHS R01 DA016351
6 · The paper itself

Abstract

objectiveSmokers often smoke during stressful events, which leads to large increases in cardiovascular measures such as blood pressure (BP) and heart rate (HR). Because exaggerated cardiovascular response to stress is associated with cardiovascular disease risk, this study examined paroxetine's effect on the physiological response to combining stress and smoking.

methodsSixty-two participants completed this randomized, double-blind, crossover study in which BP, HR, plasma epinephrine, norepinephrine, and cortisol concentrations were measured at rest, while smoking, and during a speech and math task. Laboratory sessions occurred after 1 month of paroxetine and after 1 month of placebo.

resultsSignificant increases occurred for all measures (except cortisol) during smoking, with further increases occurring during the speech task (time effect, p < .001). After 1 month of paroxetine, norepinephrine and HR values were lower and cortisol values were higher (versus placebo) throughout the laboratory session (treatment effect, p < .001). Treatment × time effects were observed for BP and HR (all, p < .01). For systolic and diastolic BP, a smaller increase (from baseline to measures during speech) was observed after paroxetine compared with placebo (both, p < .006). In both measures, the increase in response to smoking was similar for both treatments; however, the further increase during the speech was smaller when taking paroxetine (versus placebo).

conclusionsThis study suggests that paroxetine affects physiological response to stress in smokers. Further research is needed to determine the impact of these results on cardiovascular health. Trial Registration clinicaltrials.gov Identifier: NCT00218439.

Indexed as

AdultAntidepressive Agents, Second-GenerationBlood PressureCross-Over StudiesDouble-Blind MethodEpinephrineFemaleHeart RateHumansHydrocortisoneMaleNorepinephrineParoxetineSmokingStress, PsychologicalAntidepressive Agents, Second-GenerationEpinephrineHydrocortisoneNorepinephrineParoxetine

Identifiers

PMID23504241
PMCPMC3721515
OpenAlexW2146569797

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.