ReviewProtoplasma2013
The very many faces of presenilins and the γ-secretase complex.
Review in Protoplasma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Pooled it
- The manipulator behind "Scissors": γ -secretase and its modulators in Alzheimer's disease.Frontiers in aging neuroscience · 2025Review
- Genomes of fungi and relatives reveal delayed loss of ancestral gene families and evolution of key fungal traits.Nature ecology & evolution · 2023Article
- Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction.Antioxidants (Basel, Switzerland) · 2022Article
- Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration.Aging cell · 2021Article
- GATA1-regulated JAG1 promotes ovarian cancer progression by activating Notch signal pathway.Protoplasma · 2020Article
- Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer's Disease Pathology.International journal of molecular sciences · 2020Article
- Corrupted ER-mitochondrial calcium homeostasis promotes the collapse of proteostasis.Aging cell · 2020Article
- Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration inAntioxidants (Basel, Switzerland) · 2018Review
- Effects of grape seed proanthocyanidin on Alzheimer's diseaseExperimental and therapeutic medicine · 2016Article
- Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production.Journal of cellular and molecular medicine · 2016Article
- Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism.Arthritis research & therapy · 2015Article
- Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer's disease.Frontiers in cellular neuroscience · 2015Review
- Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana.Journal of experimental botany · 2014Article
- Effects of aluminium on β-amyloid (1-42) and secretases (APP-cleaving enzymes) in rat brain.Neurochemical research · 2014Article
- Autophagic/lysosomal dysfunction in Alzheimer's disease.Alzheimer's research & therapy · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Presenilin is a central, catalytic component of the γ-secretase complex which conducts intramembrane cleavage of various protein substrates. Although identified and mainly studied through its role in the development of amyloid plaques in Alzheimer disease, γ-secretase has many other important functions. The complex seems to be evolutionary conserved throughout the Metazoa, but recent findings in plants and Dictyostelium discoideum as well as in archeons suggest that its evolution and functions might be much more diversified than previously expected. In this review, a selective survey of the multitude of functions of presenilins and the γ-secretase complex is presented. Following a brief overview of γ-secretase structure, assembly and maturation, three functional aspects are analyzed: (1) the role of γ-secretase in autophagy and phagocytosis; (2) involvement of the complex in signaling related to endocytosis; and (3) control of calcium fluxes by presenilins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.